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Left ventricular hypertrophy and drugs of ingredients of divalproex sodium (a real world drug study)


Summary:

Left ventricular hypertrophy is found among people who take drugs with ingredients of divalproex sodium, especially for people who are male, 30-39 old , have been taking the drugs for 2 - 5 years. This phase IV clinical study is created by eHealthMe based on reports of 67,439 people who have side effects when taking drugs with ingredients of divalproex sodium from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Depakote, Depakote cp, Depakote er, Divalproex, Divalproex sodium, Epival.

On Jul, 31, 2026

67,439 people reported to have side effects when taking drugs with ingredients of divalproex sodium.
Among them, 30 people (0.04%) have Left ventricular hypertrophy

What is Left ventricular hypertrophy?

Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart) is found to be associated with 896 drugs and 756 conditions by eHealthMe. Check the latest studies of Left ventricular hypertrophy.

Number of reports submitted per year:

Could drugs with ingredients of divalproex sodium cause Left ventricular hypertrophy?

Time on drugs with ingredients of divalproex sodium when people have Left ventricular hypertrophy *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Left ventricular hypertrophy when taking drugs with ingredients of divalproex sodium *:

  • female: 23.33 %
  • male: 76.67 %

Age of people who have Left ventricular hypertrophy when taking drugs with ingredients of divalproex sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 12 %
  • 30-39: 44 %
  • 40-49: 4 %
  • 50-59: 20 %
  • 60+: 20 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Agitation (state of anxiety or nervous excitement): 7 people, 23.33%
  2. Stress And Anxiety: 5 people, 16.67%
  3. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 13.33%
  4. Salivary Hypersecretion (excess saliva secretion): 3 people, 10.00%
  5. Pain: 3 people, 10.00%
  6. Depression: 3 people, 10.00%
  7. Vestibular Disorder (disorders of the body's balance (vestibular) system in the inner ear): 2 people, 6.67%
  8. Dizziness: 2 people, 6.67%
  9. Psychotic Disorder: 2 people, 6.67%
  10. Back Disorder: 2 people, 6.67%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Tylenol: 10 people, 33.33%
  2. Pantoprazole: 8 people, 26.67%
  3. Gliclazide: 8 people, 26.67%
  4. Melatonin: 8 people, 26.67%
  5. Metformin: 8 people, 26.67%
  6. Atropine: 7 people, 23.33%
  7. Zyprexa: 6 people, 20.00%
  8. Clonazepam: 6 people, 20.00%
  9. Clozapine: 6 people, 20.00%
  10. Glycopyrrolate: 6 people, 20.00%

Other side effects people have besides Left ventricular hypertrophy *:

You may use this to check any potential undetected side effects.

  1. Weight Increased: 14 people, 46.67%
  2. High Blood Pressure: 13 people, 43.33%
  3. Tremor (trembling or shaking movements in one or more parts of your body): 12 people, 40.00%
  4. Diabetes: 10 people, 33.33%
  5. Electrocardiogram Qrs Complex Prolonged: 9 people, 30.00%
  6. Long Qt Syndrome (disorder of the heart's electrical system): 8 people, 26.67%
  7. Salivary Hypersecretion (excess saliva secretion): 8 people, 26.67%
  8. Glycosylated Haemoglobin Increased: 8 people, 26.67%
  9. Electrocardiogram Abnormal: 8 people, 26.67%
  10. Mitral Valve Incompetence (inefficient heart valve): 7 people, 23.33%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of divalproex sodium, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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