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Colonic perforation and drugs of ingredients of etanercept (a real world drug study)


Summary:

Colonic perforation is found among people who take drugs with ingredients of etanercept, especially for people who are female, 50-59 old , have been taking the drugs for 6 - 12 months. This phase IV clinical study is created by eHealthMe based on reports of 681,762 people who have side effects when taking drugs with ingredients of etanercept from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Enbrel.

On Aug, 12, 2026

681,762 people reported to have side effects when taking drugs with ingredients of etanercept.
Among them, 18 people (0.0%) have Colonic perforation

What is Colonic perforation?

Colonic perforation (a hole in the colon) is found to be associated with 37 drugs and 52 conditions by eHealthMe. Check the latest studies of Colonic perforation.

Number of reports submitted per year:

Could drugs with ingredients of etanercept cause Colonic perforation?

Time on drugs with ingredients of etanercept when people have Colonic perforation *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Colonic perforation when taking drugs with ingredients of etanercept *:

  • female: 64.71 %
  • male: 35.29 %

Age of people who have Colonic perforation when taking drugs with ingredients of etanercept *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 6.25 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 50.0 %
  • 60+: 43.75 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.56%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Prednisone: 9 people, 50.00%
  2. Zolpidem Tartrate: 3 people, 16.67%
  3. Phenytoin: 3 people, 16.67%
  4. Pantoprazole: 3 people, 16.67%
  5. Pamidronate Disodium: 3 people, 16.67%
  6. Ranitidine: 2 people, 11.11%
  7. Furosemide: 2 people, 11.11%
  8. Glipizide: 2 people, 11.11%
  9. Methylprednisolone: 2 people, 11.11%
  10. Levothyroxine Sodium: 1 person, 5.56%

Other side effects people have besides Colonic perforation *:

You may use this to check any potential undetected side effects.

  1. Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 7 people, 38.89%
  2. Multi-Organ Failure (multisystem organ failure): 2 people, 11.11%
  3. Colon Gangrene (colon tissue dies): 2 people, 11.11%
  4. Liver Function Tests Nos Abnormal: 2 people, 11.11%
  5. Intestinal Ischaemia (decreased supply of oxygenated blood to the intestines): 2 people, 11.11%
  6. White Blood Cell Count Increased: 2 people, 11.11%
  7. Fever: 2 people, 11.11%
  8. Wound Dehiscence (a surgical incision reopens either internally or externally): 1 person, 5.56%
  9. Culture Wound Positive: 1 person, 5.56%
  10. Arm Amputation: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of etanercept, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on etanercept. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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