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Areflexia and drugs of ingredients of fluorouracil (a real world drug study)


Summary:

Areflexia is found among people who take drugs with ingredients of fluorouracil, especially for people who are male, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 99,446 people who have side effects when taking drugs with ingredients of fluorouracil from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Adrucil, Carac, Efudex, Fluoroplex, Fluorouracil, Tolak.

On Aug, 02, 2026

99,446 people reported to have side effects when taking drugs with ingredients of fluorouracil.
Among them, 31 people (0.03%) have Areflexia

What is Areflexia?

Areflexia (absence of a reflex) is found to be associated with 432 drugs and 726 conditions by eHealthMe. Check the latest studies of Areflexia.

Number of reports submitted per year:

Could drugs with ingredients of fluorouracil cause Areflexia?

Time on drugs with ingredients of fluorouracil when people have Areflexia *:

  • < 1 month: 33.33 %
  • 1 - 6 months: 16.67 %
  • 6 - 12 months: 33.33 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 16.67 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Areflexia when taking drugs with ingredients of fluorouracil *:

  • female: 37.93 %
  • male: 62.07 %

Age of people who have Areflexia when taking drugs with ingredients of fluorouracil *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 6.9 %
  • 50-59: 24.14 %
  • 60+: 68.97 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 7 people, 22.58%
  2. Colon Cancer: 3 people, 9.68%
  3. Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 6.45%
  4. Rectal Cancer (cancer of rectum): 2 people, 6.45%
  5. Neoplasm Malignant (cancer tumour): 2 people, 6.45%
  6. Tumor: 1 person, 3.23%
  7. Tonsil Cancer: 1 person, 3.23%
  8. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 3.23%
  9. Neuralgia (pain in one or more nerves): 1 person, 3.23%
  10. Metastases To Peritoneum (cancer spreads to peritoneum): 1 person, 3.23%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Leucovorin Calcium: 9 people, 29.03%
  2. Eloxatin: 8 people, 25.81%
  3. Oxaliplatin: 7 people, 22.58%
  4. Capecitabine: 4 people, 12.90%
  5. Irinotecan Hydrochloride: 4 people, 12.90%
  6. Avastin: 4 people, 12.90%
  7. Kytril: 3 people, 9.68%
  8. Benadryl: 3 people, 9.68%
  9. Fentanyl: 2 people, 6.45%
  10. Decadron: 2 people, 6.45%

Other side effects people have besides Areflexia *:

You may use this to check any potential undetected side effects.

  1. Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 9 people, 29.03%
  2. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 9 people, 29.03%
  3. Respiratory Distress (difficulty in breathing): 8 people, 25.81%
  4. Weakness: 7 people, 22.58%
  5. High Blood Pressure: 6 people, 19.35%
  6. Nausea And Vomiting: 5 people, 16.13%
  7. Guillain-Barre Syndrome (the body's immune system attacks its peripheral nervous system): 5 people, 16.13%
  8. Consciousness - Decreased: 5 people, 16.13%
  9. Blood Potassium Decreased: 5 people, 16.13%
  10. Blood Alkaline Phosphatase Increased: 5 people, 16.13%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of fluorouracil, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on fluorouracil. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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