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Skin fragility and drugs of ingredients of lactulose (a real world drug study)


Summary:

Skin fragility is found among people who take drugs with ingredients of lactulose, especially for people who are male, 60+ old . This phase IV clinical study is created by eHealthMe based on reports of 53,617 people who have side effects when taking drugs with ingredients of lactulose from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Acilac, Cephulac, Cholac, Chronulac, Constilac, Constulose, Duphalac, Enulose, Evalose, Generlac, Heptalac, Lactulose, Laxilose, Portalac.

On Jul, 29, 2026

53,617 people reported to have side effects when taking drugs with ingredients of lactulose.
Among them, 18 people (0.03%) have Skin fragility

What is Skin fragility?

Skin fragility (trauma-induced blisters and erosions of skin) is found to be associated with 198 drugs and 250 conditions by eHealthMe. Check the latest studies of Skin fragility.

Number of reports submitted per year:

Could drugs with ingredients of lactulose cause Skin fragility?

Gender of people who have Skin fragility when taking drugs with ingredients of lactulose *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Skin fragility when taking drugs with ingredients of lactulose *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 37.5 %
  • 60+: 62.5 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Psoriasis (immune-mediated disease that affects the skin): 11 people, 61.11%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 27.78%
  3. Subacute Endocarditis (bacterial infection that produces growths on the endocardium (the cells lining the inside of the heart)): 1 person, 5.56%
  4. Splenomegaly (enlargement of spleen): 1 person, 5.56%
  5. Nausea And Vomiting: 1 person, 5.56%
  6. Nausea (feeling of having an urge to vomit): 1 person, 5.56%
  7. High Blood Pressure: 1 person, 5.56%
  8. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 5.56%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Humira: 11 people, 61.11%
  2. Pantoprazole: 11 people, 61.11%
  3. Epipen: 11 people, 61.11%
  4. Cymbalta: 11 people, 61.11%
  5. Cosentyx: 11 people, 61.11%
  6. Lyrica: 11 people, 61.11%
  7. Enbrel: 11 people, 61.11%
  8. Synthroid: 11 people, 61.11%
  9. Stelara: 11 people, 61.11%
  10. Calcipotriene And Betamethasone Dipropionate: 10 people, 55.56%

Other side effects people have besides Skin fragility *:

You may use this to check any potential undetected side effects.

  1. High Blood Pressure: 16 people, 88.89%
  2. Pain: 16 people, 88.89%
  3. Blood Pressure Fluctuation: 16 people, 88.89%
  4. Weakness: 11 people, 61.11%
  5. Rashes (redness): 11 people, 61.11%
  6. Fatigue (feeling of tiredness): 11 people, 61.11%
  7. Hypersensitivity: 11 people, 61.11%
  8. Psoriasis (immune-mediated disease that affects the skin): 11 people, 61.11%
  9. Hot Flush (sudden feelings of heat): 11 people, 61.11%
  10. Thermal Burn (burn by heat): 11 people, 61.11%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of lactulose, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on lactulose. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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