Apraxia and drugs of ingredients of lamotrigine - a phase IV clinical study of FDA data


Apraxia is found among people who take drugs with ingredients of lamotrigine, especially for people who are female, 20-29 old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 128,479 people who have side effects when taking drugs with ingredients of lamotrigine from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Lamictal, Lamictal cd, Lamictal odt, Lamictal xr, Lamotrigine.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2022

128,479 people reported to have side effects when taking drugs with ingredients of lamotrigine.
Among them, 45 people (0.04%) have Apraxia

What is Apraxia?

Apraxia (disorder that affects a person's ability to organize the movements of the muscles used in speech) is found to be associated with 1,005 drugs and 828 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of lamotrigine cause Apraxia?

Time on drugs with ingredients of lamotrigine when people have Apraxia *:

  • < 1 month: 60 %
  • 1 - 6 months: 40 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Apraxia when taking drugs with ingredients of lamotrigine *:

  • female: 77.27 %
  • male: 22.73 %

Age of people who have Apraxia when taking drugs with ingredients of lamotrigine *:

  • 0-1: 0.0 %
  • 2-9: 7.5 %
  • 10-19: 2.5 %
  • 20-29: 35.0 %
  • 30-39: 5.0 %
  • 40-49: 10.0 %
  • 50-59: 22.5 %
  • 60+: 17.5 %

Conditions people have *:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 11.11%
  2. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 4.44%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 4.44%
  4. Headache (pain in head): 2 people, 4.44%
  5. Depression: 2 people, 4.44%
  6. Spinal Column Stenosis (narrowing of spinal column): 1 person, 2.22%
  7. Partial Seizures (seizures which affect only a part of the brain at onset): 1 person, 2.22%
  8. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 1 person, 2.22%
  9. Migraine (headache): 1 person, 2.22%
  10. Lymphomatoid Papulosis (a skin disorder that is characterized by crops of self healing skin lesions): 1 person, 2.22%

Other drugs people take *:

  1. Depakene: 4 people, 8.89%
  2. Zoloft: 3 people, 6.67%
  3. Neurontin: 3 people, 6.67%
  4. Plavix: 3 people, 6.67%
  5. Gabitril: 3 people, 6.67%
  6. Valproate Sodium: 3 people, 6.67%
  7. Depakote: 3 people, 6.67%
  8. Tylenol: 2 people, 4.44%
  9. Klonopin: 2 people, 4.44%
  10. Dilantin: 2 people, 4.44%

Other side effects people have besides Apraxia *:

  1. Nausea And Vomiting: 17 people, 37.78%
  2. Confusional State: 12 people, 26.67%
  3. Tremor (trembling or shaking movements in one or more parts of your body): 9 people, 20.00%
  4. Speech Impairment (Adult) (inability to speak (adult)): 9 people, 20.00%
  5. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 7 people, 15.56%
  6. Agitation (state of anxiety or nervous excitement): 7 people, 15.56%
  7. Balance Disorder: 7 people, 15.56%
  8. Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light): 5 people, 11.11%
  9. Memory Loss: 5 people, 11.11%
  10. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 5 people, 11.11%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Drugs with ingredients of lamotrigine, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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