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Hyperthyroidism and drugs of ingredients of letrozole (a real world drug study)


Summary:

Hyperthyroidism is found among people who take drugs with ingredients of letrozole, especially for people who are female, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 71,546 people who have side effects when taking drugs with ingredients of letrozole from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Femara, Letrozole.

On Dec, 07, 2025

71,546 people reported to have side effects when taking drugs with ingredients of letrozole.
Among them, 114 people (0.16%) have Hyperthyroidism

What is Hyperthyroidism?

Hyperthyroidism (over activity of the thyroid gland) is found to be associated with 1,044 drugs and 1,417 conditions by eHealthMe. Check the latest studies of Hyperthyroidism.

Number of reports submitted per year:

Could drugs with ingredients of letrozole cause Hyperthyroidism?

Time on drugs with ingredients of letrozole when people have Hyperthyroidism *:

  • < 1 month: 50 %
  • 1 - 6 months: 30 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 20 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hyperthyroidism when taking drugs with ingredients of letrozole *:

  • female: 98.21 %
  • male: 1.79 %

Age of people who have Hyperthyroidism when taking drugs with ingredients of letrozole *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 1.33 %
  • 40-49: 24.0 %
  • 50-59: 26.67 %
  • 60+: 48.0 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. High Blood Pressure: 16 people, 14.04%
  2. Metastases To Bone (cancer spreads to bone): 15 people, 13.16%
  3. Oedema (fluid collection in tissue): 10 people, 8.77%
  4. Depression: 10 people, 8.77%
  5. Pain: 7 people, 6.14%
  6. Neoplasm Malignant (cancer tumour): 7 people, 6.14%
  7. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 5.26%
  8. Chronic Thyroiditis (long lasting inflammation of thyroid gland): 5 people, 4.39%
  9. Hyperchlorhydria (gastric acid levels are higher in stomach): 4 people, 3.51%
  10. Flatulence (flatus expelled through the anus): 4 people, 3.51%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Kisqali: 42 people, 36.84%
  2. Taxol: 12 people, 10.53%
  3. Valium: 12 people, 10.53%
  4. Zometa: 11 people, 9.65%
  5. Cytoxan: 11 people, 9.65%
  6. Methotrexate: 11 people, 9.65%
  7. Ativan: 11 people, 9.65%
  8. Aredia: 11 people, 9.65%
  9. Gemzar: 10 people, 8.77%
  10. Compazine: 10 people, 8.77%

Other side effects people have besides Hyperthyroidism *:

You may use this to check any potential undetected side effects.

  1. Dyspnea (difficult or laboured breathing): 25 people, 21.93%
  2. Pneumonia: 22 people, 19.30%
  3. Anaemia (lack of blood): 21 people, 18.42%
  4. Stress And Anxiety: 20 people, 17.54%
  5. Cough: 18 people, 15.79%
  6. Nausea (feeling of having an urge to vomit): 17 people, 14.91%
  7. Fatigue (feeling of tiredness): 17 people, 14.91%
  8. General Physical Health Deterioration (weak health status): 17 people, 14.91%
  9. Weight Decreased: 15 people, 13.16%
  10. Weight Increased: 14 people, 12.28%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

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Drugs with ingredients of letrozole, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on letrozole. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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