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Coma and drugs of ingredients of same (a real world drug study)


Summary:

Coma is found among people who take drugs with ingredients of same, especially for people who are male, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 1,178 people who have side effects when taking drugs with ingredients of same from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Ademetionine, Adenosylmethionine, S-adenosyl-l-methionine, Sam-e, Same, Sammy.

On Jun, 24, 2026

1,178 people reported to have side effects when taking drugs with ingredients of same.
Among them, 8 people (0.68%) have Coma

What is Coma?

Coma (state of unconsciousness lasting more than six hours) is found to be associated with 2,774 drugs and 3,208 conditions by eHealthMe. Check the latest studies of Coma.

Number of reports submitted per year:

Could drugs with ingredients of same cause Coma?

Time on drugs with ingredients of same when people have Coma *:

  • < 1 month: 66.67 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 33.33 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Coma when taking drugs with ingredients of same *:

  • female: 37.5 %
  • male: 62.5 %

Age of people who have Coma when taking drugs with ingredients of same *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 37.50%
  2. Colon Cancer: 3 people, 37.50%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 37.50%
  4. Hepatic Neoplasm Malignant (liver cancer): 2 people, 25.00%
  5. Bone Disorder: 1 person, 12.50%
  6. Bladder Disorder: 1 person, 12.50%
  7. Affective Disorder (mental disorder): 1 person, 12.50%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Xyrem: 3 people, 37.50%
  2. Clemastine Fumarate: 3 people, 37.50%
  3. Dexamethasone: 3 people, 37.50%
  4. Oxaliplatin: 3 people, 37.50%
  5. Thioctic Acid: 3 people, 37.50%
  6. Sorafenib: 2 people, 25.00%
  7. Coenzyme Q10: 2 people, 25.00%
  8. Oxybutynin: 2 people, 25.00%
  9. Fluorouracil: 2 people, 25.00%
  10. Linzess: 2 people, 25.00%

Other side effects people have besides Coma *:

You may use this to check any potential undetected side effects.

  1. Apnea (temporary absence or cessation of breathing): 3 people, 37.50%
  2. Haemorrhagic Stroke (stroke caused by the rupture of a blood vessel in the brain): 3 people, 37.50%
  3. Fatigue (feeling of tiredness): 2 people, 25.00%
  4. Ascites (accumulation of fluid in the abdominal cavity): 2 people, 25.00%
  5. Confusional State: 2 people, 25.00%
  6. Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 2 people, 25.00%
  7. Hepatic Function Abnormal: 2 people, 25.00%
  8. Weakness: 2 people, 25.00%
  9. Blood Sodium Decreased: 1 person, 12.50%
  10. Catatonia (unresponsive to external stimuli): 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of same, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on same. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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