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Low thyroid and drugs of ingredients of same (a real world drug study)


Summary:

Low thyroid is found among people who take drugs with ingredients of same, especially for people who are male, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 1,178 people who have side effects when taking drugs with ingredients of same from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Ademetionine, Adenosylmethionine, S-adenosyl-l-methionine, Sam-e, Same, Sammy.

On Jun, 19, 2026

1,178 people reported to have side effects when taking drugs with ingredients of same.
Among them, 13 people (1.1%) have Low thyroid

What is Low thyroid?

Low thyroid (abnormally low thyroid hormone production) is found to be associated with 2,674 drugs and 2,640 conditions by eHealthMe. Check the latest studies of Low thyroid.

Number of reports submitted per year:

Could drugs with ingredients of same cause Low thyroid?

Time on drugs with ingredients of same when people have Low thyroid *:

  • < 1 month: 50 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Low thyroid when taking drugs with ingredients of same *:

  • female: 30.77 %
  • male: 69.23 %

Age of people who have Low thyroid when taking drugs with ingredients of same *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 23.08 %
  • 50-59: 15.38 %
  • 60+: 61.54 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Joint Pain: 6 people, 46.15%
  2. Urination - Excessive Volume: 4 people, 30.77%
  3. Lung Cancer - Non-Small Cell (lung cancer): 4 people, 30.77%
  4. Conjunctivitis (pink eye): 4 people, 30.77%
  5. Cough: 4 people, 30.77%
  6. Productive Cough: 4 people, 30.77%
  7. Pericardial Effusion (fluid around the heart): 4 people, 30.77%
  8. Hyperglycemia (high blood sugar): 4 people, 30.77%
  9. Ligament Sprain (ligament stretched): 4 people, 30.77%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 15.38%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Gliclazide: 4 people, 30.77%
  2. Spironolactone: 4 people, 30.77%
  3. Sitagliptin Phosphate: 4 people, 30.77%
  4. Arava: 3 people, 23.08%
  5. Mobic: 3 people, 23.08%
  6. Nexium: 3 people, 23.08%
  7. Creon: 2 people, 15.38%
  8. Fosamax: 2 people, 15.38%
  9. Flexeril: 2 people, 15.38%
  10. Flaxseed: 2 people, 15.38%

Other side effects people have besides Low thyroid *:

You may use this to check any potential undetected side effects.

  1. Fatigue (feeling of tiredness): 4 people, 30.77%
  2. Blood Creatine Phosphokinase Increased: 4 people, 30.77%
  3. Weakness: 4 people, 30.77%
  4. Haemoglobin Decreased: 3 people, 23.08%
  5. Oedema Peripheral (superficial swelling): 3 people, 23.08%
  6. Pain: 3 people, 23.08%
  7. Weight Decreased: 2 people, 15.38%
  8. Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 2 people, 15.38%
  9. Gastrointestinal Perforation (hole in the digestive tract): 2 people, 15.38%
  10. Feeling Abnormal: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of same, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on same. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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