Edema and drugs of ingredients of sofosbuvir (a real world drug study)


Summary:

Edema is found among people who take drugs with ingredients of sofosbuvir, especially for people who are male, 60+ old , have been taking the drugs for 1 - 6 months. This phase IV clinical study is created by eHealthMe based on reports of 21,826 people who have side effects when taking drugs with ingredients of sofosbuvir from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Sofosbuvir, Sovaldi.


On Jun, 21, 2026

21,826 people reported to have side effects when taking drugs with ingredients of sofosbuvir.
Among them, 42 people (0.19%) have Edema


What is Edema?

Edema (excess of watery fluid collecting in the cavities or tissues of the body) is found to be associated with 2,301 drugs and 2,870 conditions by eHealthMe. Check the latest studies of Edema.

Number of reports submitted per year:

Could drugs with ingredients of sofosbuvir cause Edema?

Time on drugs with ingredients of sofosbuvir when people have Edema *:

  • < 1 month: 12.5 %
  • 1 - 6 months: 75.0 %
  • 6 - 12 months: 12.5 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Edema when taking drugs with ingredients of sofosbuvir *:

  • female: 38.1 %
  • male: 61.9 %

Age of people who have Edema when taking drugs with ingredients of sofosbuvir *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 21.88 %
  • 50-59: 34.38 %
  • 60+: 43.75 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Hepatitis C: 21 people, 50.00%
  2. Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 2 people, 4.76%
  3. Thrombocytopenia (decrease of platelets in blood): 1 person, 2.38%
  4. Psoriasis (immune-mediated disease that affects the skin): 1 person, 2.38%
  5. Portal Hypertension (increase in the blood pressure within a system of veins called the portal venous system): 1 person, 2.38%
  6. Otitis (ear infection): 1 person, 2.38%
  7. Insomnia (sleeplessness): 1 person, 2.38%
  8. Hepatitis (inflammation of the liver): 1 person, 2.38%
  9. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue): 1 person, 2.38%
  10. Depression: 1 person, 2.38%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Olysio: 7 people, 16.67%
  2. Daklinza: 6 people, 14.29%
  3. Ribavirin: 4 people, 9.52%
  4. Pegasys: 3 people, 7.14%
  5. Copegus: 2 people, 4.76%
  6. Hydrocodone: 2 people, 4.76%
  7. Lasix: 2 people, 4.76%
  8. Lyrica: 2 people, 4.76%
  9. Concerta: 2 people, 4.76%
  10. Coreg: 1 person, 2.38%

Other side effects people have besides Edema *:

You may use this to check any potential undetected side effects.

  1. Fatigue (feeling of tiredness): 10 people, 23.81%
  2. Nausea (feeling of having an urge to vomit): 9 people, 21.43%
  3. Rashes (redness): 7 people, 16.67%
  4. Pain: 7 people, 16.67%
  5. Headache (pain in head): 6 people, 14.29%
  6. Malaise (a feeling of general discomfort or uneasiness): 5 people, 11.90%
  7. Diarrhea: 5 people, 11.90%
  8. Dyspnea (difficult or laboured breathing): 5 people, 11.90%
  9. Abdominal Pain: 5 people, 11.90%
  10. Weakness: 4 people, 9.52%

* Approximation only. Some reports may have incomplete information.


How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of sofosbuvir, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on sofosbuvir. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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