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Headache and drugs of ingredients of sofosbuvir (a real world drug study)


Summary:

Headache is found among people who take drugs with ingredients of sofosbuvir, especially for people who are male, 50-59 old , have been taking the drugs for 1 - 6 months. This phase IV clinical study is created by eHealthMe based on reports of 21,826 people who have side effects when taking drugs with ingredients of sofosbuvir from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Sofosbuvir, Sovaldi.

On Jan, 12, 2026

21,826 people reported to have side effects when taking drugs with ingredients of sofosbuvir.
Among them, 1,857 people (8.51%) have Headache

What is Headache?

Headache (pain in head) is found to be associated with 3,745 drugs and 5,743 conditions by eHealthMe. Check the latest studies of Headache.

Number of reports submitted per year:

Could drugs with ingredients of sofosbuvir cause Headache?

Time on drugs with ingredients of sofosbuvir when people have Headache *:

  • < 1 month: 16.06 %
  • 1 - 6 months: 79.82 %
  • 6 - 12 months: 2.75 %
  • 1 - 2 years: 0.92 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.46 %

Gender of people who have Headache when taking drugs with ingredients of sofosbuvir *:

  • female: 45.25 %
  • male: 54.75 %

Age of people who have Headache when taking drugs with ingredients of sofosbuvir *:

  • 0-1: 0.09 %
  • 2-9: 0.0 %
  • 10-19: 0.17 %
  • 20-29: 2.7 %
  • 30-39: 7.92 %
  • 40-49: 13.49 %
  • 50-59: 46.13 %
  • 60+: 29.5 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Hepatitis C: 744 people, 40.06%
  2. High Blood Pressure: 26 people, 1.40%
  3. Pain: 21 people, 1.13%
  4. Hepatitis (inflammation of the liver): 19 people, 1.02%
  5. Stress And Anxiety: 18 people, 0.97%
  6. Depression: 17 people, 0.92%
  7. Hiv Infection: 16 people, 0.86%
  8. Blood Pressure Abnormal: 15 people, 0.81%
  9. Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 14 people, 0.75%
  10. Insomnia (sleeplessness): 12 people, 0.65%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Ribavirin: 277 people, 14.92%
  2. Pegasys: 257 people, 13.84%
  3. Norfloxacin: 232 people, 12.49%
  4. Hydrochlorothiazide: 216 people, 11.63%
  5. Glucosamine: 215 people, 11.58%
  6. Acetaminophen: 215 people, 11.58%
  7. Pentoxifylline: 214 people, 11.52%
  8. Telmisartan: 214 people, 11.52%
  9. Nitroglycerin: 214 people, 11.52%
  10. Fenofibrate: 213 people, 11.47%

Other side effects people have besides Headache *:

You may use this to check any potential undetected side effects.

  1. Fatigue (feeling of tiredness): 889 people, 47.87%
  2. Nausea (feeling of having an urge to vomit): 629 people, 33.87%
  3. Insomnia (sleeplessness): 548 people, 29.51%
  4. Itching: 391 people, 21.06%
  5. Dizziness: 389 people, 20.95%
  6. Weakness: 380 people, 20.46%
  7. Diarrhea: 378 people, 20.36%
  8. Joint Pain: 355 people, 19.12%
  9. Muscle Aches (muscle pain): 354 people, 19.06%
  10. Dyspnea (difficult or laboured breathing): 336 people, 18.09%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of sofosbuvir, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on sofosbuvir. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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