Aphthous stomatitis and drugs of ingredients of zoledronic acid (a real world drug study)


Summary:

Aphthous stomatitis is found among people who take drugs with ingredients of zoledronic acid, especially for people who are female, 60+ old , have been taking the drugs for 2 - 5 years. This phase IV clinical study is created by eHealthMe based on reports of 115,118 people who have side effects when taking drugs with ingredients of zoledronic acid from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Reclast, Zoledronic, Zoledronic acid, Zometa.


On Jun, 17, 2026

115,118 people reported to have side effects when taking drugs with ingredients of zoledronic acid.
Among them, 130 people (0.11%) have Aphthous stomatitis


What is Aphthous stomatitis?

Aphthous stomatitis (mouth ulcer) is found to be associated with 438 drugs and 811 conditions by eHealthMe. Check the latest studies of Aphthous stomatitis.

Number of reports submitted per year:

Could drugs with ingredients of zoledronic acid cause Aphthous stomatitis?

Time on drugs with ingredients of zoledronic acid when people have Aphthous stomatitis *:

  • < 1 month: 15.91 %
  • 1 - 6 months: 15.91 %
  • 6 - 12 months: 9.09 %
  • 1 - 2 years: 13.64 %
  • 2 - 5 years: 45.45 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Aphthous stomatitis when taking drugs with ingredients of zoledronic acid *:

  • female: 73.02 %
  • male: 26.98 %

Age of people who have Aphthous stomatitis when taking drugs with ingredients of zoledronic acid *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.88 %
  • 30-39: 1.77 %
  • 40-49: 21.24 %
  • 50-59: 26.55 %
  • 60+: 49.56 %

Conditions people have *:

You may use this to check any potential undetected conditions.

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Other drugs people take *:

You may use this to check any potential interacting drugs.

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Other side effects people have besides Aphthous stomatitis *:

You may use this to check any potential undetected side effects.

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* Approximation only. Some reports may have incomplete information.


How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

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How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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