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Pifeltro and Truvada drug interactions for men aged 50-59 (a phase IV clinical study of FDA data)

Summary:

Drug interactions are found for men aged 50-59 who take Pifeltro (doravirine) and Truvada (emtricitabine; tenofovir disoproxil fumarate) together. We list drug interactions by the duration when the drugs are taken. This phase IV study is created by eHealthMe based on reports of 18 people from the FDA, and is updated regularly.

On Mar, 29, 2026

18 men aged 50-59 who take Pifeltro, Truvada and have drug interactions are studied.

What is Pifeltro?

Pifeltro has active ingredients of doravirine. eHealthMe is studying from 476 Pifeltro users. Check the latest studies of Pifeltro.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

Number of reports submitted per year:

Pifeltro and Truvada drug interactions in men aged 50-59.

Most common drug interactions over time *:

< 1 month:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Back injury
  4. Chest injury
  5. Chronic kidney disease
  6. Depression
  7. Emotional distress
  8. Foot fracture
  9. Joint injury
  10. Limb injury

1 - 6 months:

  1. Bone density decreased
  2. Chronic kidney disease
  3. Emotional distress
  4. Exercise tolerance decreased
  5. Foot fracture
  6. Lumbar vertebral fracture
  7. Mobility decreased (ability to move is reduced)
  8. Multiple fractures
  9. Myelitis (infection or the inflammation of white matter or gray matter of spinal cord which is a part of central nervous system)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

6 - 12 months:

  1. Chronic kidney disease
  2. Emotional distress
  3. Foot fracture
  4. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  5. Osteoporosis (bones weak and more likely to break)
  6. Pain
  7. Bone density decreased
  8. Exercise tolerance decreased
  9. Lumbar vertebral fracture
  10. Mobility decreased (ability to move is reduced)

1 - 2 years:

  1. Bone density decreased
  2. Renal failure (kidney dysfunction)
  3. Tooth loss
  4. Chronic kidney disease
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  6. Bone pain
  7. Dysstasia (difficulty in standing)
  8. Foot fracture
  9. Gait disturbance
  10. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

2 - 5 years:

  1. Emotional distress
  2. Pain
  3. Chronic kidney disease
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  5. Anxiety
  6. Renal failure (kidney dysfunction)
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  8. Osteoporosis (bones weak and more likely to break)
  9. Tooth loss
  10. Depression

5 - 10 years:

  1. Chronic kidney disease
  2. Pain
  3. Emotional distress
  4. Renal failure (kidney dysfunction)
  5. Bone density decreased
  6. Exercise tolerance decreased
  7. Multiple fractures
  8. Anxiety
  9. Foot fracture
  10. Lumbar vertebral fracture

10+ years:

  1. Bone density decreased
  2. Chronic kidney disease
  3. Osteoporosis (bones weak and more likely to break)
  4. Pain
  5. Rib fracture
  6. Spinal osteoarthritis (joint cartilage loss in spine)
  7. Emotional distress
  8. Exercise tolerance decreased
  9. Foot fracture
  10. Lumbar vertebral fracture

not specified:

  1. Pain
  2. Chronic kidney disease
  3. Emotional distress
  4. Renal failure (kidney dysfunction)
  5. Anxiety
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  8. Bone density decreased
  9. Osteoporosis (bones weak and more likely to break)
  10. Tooth loss

* Approximation only. Some reports may have incomplete information.

Do you take Pifeltro and Truvada?

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How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies:

How the study uses the data?

The study is based on (applicable) gender, age, doravirine and emtricitabine; tenofovir disoproxil fumarate (the active ingredients of Pifeltro and Truvada, respectively), and Pifeltro and Truvada (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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