Plaquenil and Cytoxan drug interactions for women aged 60+ (a phase IV clinical study of FDA data)
Summary:
Drug interactions are found for women aged 60+ who take Plaquenil (hydroxychloroquine sulfate) and Cytoxan (cyclophosphamide) together. We list drug interactions by the duration when the drugs are taken. This phase IV study is created by eHealthMe based on reports of 13 people from the FDA, and is updated regularly.
13 women aged 60+ who take Plaquenil, Cytoxan and have drug interactions are studied.
What is Plaquenil?
Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.
What is Cytoxan?
Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.
Number of reports submitted per year:

Most common drug interactions over time *:
< 1 month:
- Febrile neutropenia (fever with reduced white blood cells)
1 - 6 months:
n/a
6 - 12 months:
n/a
1 - 2 years:
n/a
2 - 5 years:
n/a
5 - 10 years:
n/a
10+ years:
n/a
not specified:
- Nausea (feeling of having an urge to vomit)
- Retinal haemorrhage (bleeding from retina)
- Pulmonary oedema (fluid accumulation in the lungs)
- Vision blurred
- Vith nerve paralysis
- White blood cell count decreased
- Abdominal pain lower
- Alopecia (absence of hair from areas of the body)
- Anxiety
- B-lymphocyte count decreased
* Approximation only. Some reports may have incomplete information.
Do you take Plaquenil and Cytoxan?
- Personalize this study to your gender, age, symptoms and drugs- Predict drug outcomes for up to one year with AI
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How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies:
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Related studies:
How the study uses the data?
The study is based on (applicable) gender, age, hydroxychloroquine sulfate and cyclophosphamide (the active ingredients of Plaquenil and Cytoxan, respectively), and Plaquenil and Cytoxan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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