A-hydrocort and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take A-hydrocort (hydrocortisone sodium succinate) and Methotrexate (methotrexate sodium). Common drug interactions include headache among females and alopecia among males.

The phase IV clinical study analyzes what interactions people have when they take A-hydrocort and Methotrexate. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is A-hydrocort?

A-hydrocort has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 636 A-hydrocort users. Check the latest studies of A-hydrocort.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

On Aug, 06, 2026

34 people who take A-hydrocort and Methotrexate together, and have interactions are studied.

A-hydrocort and Methotrexate drug interactions.

What are the common drug interactions of A-Hydrocort and Methotrexate, by gender? *:

female:

Headache (pain in head)
Drug ineffective
Nausea (feeling of having an urge to vomit)
Pain
Stress
Vomiting
Back pain
Infection
Myalgia (muscle pain)
Neck pain

male:

Alopecia (absence of hair from areas of the body)
Behcet's syndrome (involves inflammation of the blood vessels)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Immune system disorder
Lung infection
Mouth ulceration (mouth ulcers)
Mucosal inflammation (infection of mucous membrane)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Neoplasm malignant (cancer tumour)
Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of A-Hydrocort and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Colitis ulcerative (inflammation of colon with ulcer)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Electrocardiogram qt prolonged
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Hospitalisation
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Lung infection
Mucosal inflammation (infection of mucous membrane)

20-29:

Malaise (a feeling of general discomfort or uneasiness)

30-39:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)

40-49:

Asthma
Dizziness
Flushing (the warm, red condition of human skin)
Hypotension (abnormally low blood pressure)
Ill-defined disorder
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Psoriasis (immune-mediated disease that affects the skin)
Respiratory tract congestion (blockage on respiratory system)
Seasonal allergy (allergic condition due to certain season)
Sinusitis (inflammation of sinus)

50-59:

Drug ineffective
Abdominal distension
Arthralgia (joint pain)
Behcet's syndrome (involves inflammation of the blood vessels)
Blood cortisol decreased
Costochondritis (chest wall pain)
Depression
Dizziness
Frequent bowel movements
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Ankle fracture
Blood pressure increased
Chronic kidney disease
Drug ineffective
Hospitalisation
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Malaise (a feeling of general discomfort or uneasiness)
Neoplasm malignant (cancer tumour)
Pain
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 7 people, 20.59%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 14.71%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 8.82%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 5.88%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 2 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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