Abilify and Emsam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Abilify (aripiprazole) and Emsam (selegiline). Common drug interactions include incontinence among females and cervical vertebral fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Abilify and Emsam. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,454 Abilify users. Check the latest studies of Abilify.

What is Emsam?

Emsam has active ingredients of selegiline. It is often used in depression. eHealthMe is studying from 1,875 Emsam users. Check the latest studies of Emsam.

On Jul, 15, 2026

91 people who take Abilify and Emsam together, and have interactions are studied.

What are the common drug interactions of Abilify and Emsam, by gender? *:

female:

Incontinence (lack of moderation or self-control)
Increased appetite
Irritability
Ligament sprain (ligament stretched)
Menstruation irregular
Mood altered (changes in mood)
Muscle contractions involuntary (uncontrolled muscle contraction)
Muscle tightness
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Phobia (fear)

male:

Cervical vertebral fracture
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Local swelling (swelling at the site of some application of substance or injury)
Memory impairment
Muscle disorder (muscle disease)
Overdose
Rash generalised (rash on most of body parts)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Application site discolouration
Application site pain

What are the common drug interactions of Abilify and Emsam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Application site rash

30-39:

Weight increased
Cervical vertebral fracture
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cardiac failure
Suicidal ideation
Fall
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Myositis (inflammation of the muscles)
Obsessive rumination (thinking and worry or rumination is an inability to gain control over recurrent, distressing thoughts, images)
Papilloma viral infection

40-49:

Abdominal discomfort
Application site rash
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Embolic cerebral infarction (brain stroke due to obstruction of an artery)
Hypoaesthesia (reduced sense of touch or sensation)
Weight increased
Cystitis (inflammation of the wall of the bladder)
Hospitalisation
Memory impairment
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

50-59:

Abnormal faeces (abnormal stool)
Application site discolouration
Drug effect decreased
Alanine aminotransferase decreased
Aspartate aminotransferase decreased
Blood calcium decreased
Blood creatinine increased
Blood potassium decreased
Blood urea increased
Delusion (a false belief or opinion)

60+:

Memory impairment
Activities of daily living impaired
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Increased appetite
Rash generalised (rash on most of body parts)
Suicidal ideation
Weight increased
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 27 people, 29.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 19.78%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 8 people, 8.79%
Stress And Anxiety: 6 people, 6.59%
Sleep Disorder: 6 people, 6.59%
Bipolar Disorder (mood disorder): 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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