Abilify and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Abilify (aripiprazole) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include osteoporosis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Abilify and Hydrocodone. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,455 Abilify users. Check the latest studies of Abilify.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

91 people who take Abilify and Hydrocodone together, and have interactions are studied.

Abilify and Hydrocodone drug interactions.

What are the common drug interactions of Abilify and Hydrocodone, by gender? *:

female:

Osteoporosis (bones weak and more likely to break)
Retinal pigmentation (pigmentation of retina)
Ankle fracture
Depressed mood
Dizziness
Dyspepsia (indigestion)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
High density lipoprotein decreased
Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)

male:

Chronic kidney disease
Anxiety
Bone pain
Dizziness
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephrolithiasis (calculi in the kidneys)
Diabetes mellitus non-insulin-dependent

What are the common drug interactions of Abilify and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hereditary angioedema (recurrent episodes of severe swelling)
Chronic kidney disease
Anxiety
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Fibromyalgia (a long-term condition which causes pain all over the body)
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)
Nausea (feeling of having an urge to vomit)

40-49:

Anxiety
Chronic kidney disease
Diabetes mellitus non-insulin-dependent
Diabetic coma
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hypertension (high blood pressure)
Nephrolithiasis (calculi in the kidneys)
Rectal haemorrhage (bleeding from anus)
Vision blurred
Agitation (state of anxiety or nervous excitement)

50-59:

Appendicitis (inflammation of the appendix)
Back injury
Back pain
Bowel movement irregularity
Coccydynia (pain in the coccyx or tailbone area)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug resistance (reduction in effectiveness of a drug)
Dysstasia (difficulty in standing)
Dysuria (painful or difficult urination)

60+:

Chronic kidney disease
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Ankle fracture
Euphoric mood (excessively happy but may become angry or irritable)
Hip fracture
Humerus fracture (injury to the upper arm bone)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Pain: 17 people, 18.68%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 17.58%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 16.48%
Hiv Infection: 13 people, 14.29%
Stress And Anxiety: 11 people, 12.09%
High Blood Pressure: 11 people, 12.09%
High Blood Cholesterol: 10 people, 10.99%
Immunodeficiency Common Variable: 8 people, 8.79%
Asthma: 8 people, 8.79%
Hypersensitivity: 7 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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