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Abilify and Nubain drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Abilify (aripiprazole) and Nubain (nalbuphine hydrochloride). Common drug interactions include akathisia among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Abilify and Nubain. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,454 Abilify users. Check the latest studies of Abilify.

What is Nubain?

Nubain has active ingredients of nalbuphine hydrochloride. It is often used in pain. eHealthMe is studying from 1,749 Nubain users. Check the latest studies of Nubain.

On Jul, 16, 2026

20 people who take Abilify and Nubain together, and have interactions are studied.

Abilify and Nubain drug interactions.

What are the common drug interactions of Abilify and Nubain, by gender? *:

female:

  1. Akathisia (a movement disorder characterized by a feeling of inner restlessness)
  2. Alanine aminotransferase increased
  3. Blood alkaline phosphatase increased
  4. Gamma-glutamyltransferase increased
  5. Chronic kidney disease
  6. Renal failure (kidney dysfunction)
  7. Type 2 diabetes mellitus
  8. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  9. Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
  10. Dyspepsia (indigestion)

male:

  1. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  2. Abdominal pain
  3. Periumbilical abscess (abscess around the umbilicus)
  4. Polysubstance dependence
  5. Psychotic disorder
  6. Schizoaffective disorder (a mental disorder characterized by disordered thought)
  7. Schizophrenia, paranoid type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect)
  8. Sinusitis (inflammation of sinus)
  9. Diabetic retinopathy (damage to the retina caused by complications of diabetes)
  10. Type 2 diabetes mellitus

What are the common drug interactions of Abilify and Nubain, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Akathisia (a movement disorder characterized by a feeling of inner restlessness)
  2. Alanine aminotransferase increased
  3. Blood alkaline phosphatase increased
  4. Gamma-glutamyltransferase increased
  5. Obesity (having too much body fat)
  6. Type 2 diabetes mellitus

30-39:

  1. Akathisia (a movement disorder characterized by a feeling of inner restlessness)
  2. Alanine aminotransferase increased
  3. Blood alkaline phosphatase increased
  4. Gamma-glutamyltransferase increased
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Abdominal pain
  7. Chest discomfort
  8. Chest pain
  9. Diabetic coma
  10. Facial palsy (paralysis of face nerve)

40-49:

  1. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  2. Chronic kidney disease
  3. Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
  4. Renal failure (kidney dysfunction)
  5. Type 2 diabetes mellitus
  6. Dyspepsia (indigestion)
  7. Renal injury (kidney injury)
  8. Renal tubular necrosis (death of kidney tubules)

50-59:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)

60+:

  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

  1. Bipolar Disorder (mood disorder): 11 people, 55.00%
  2. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 25.00%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 25.00%
  4. High Blood Pressure: 2 people, 10.00%
  5. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 10.00%
  6. Diabetes: 2 people, 10.00%
  7. Drug Hypersensitivity: 2 people, 10.00%
  8. Urinary Tract Infection: 2 people, 10.00%
  9. High Blood Cholesterol: 2 people, 10.00%
  10. Insomnia (sleeplessness): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Abilify and Nubain?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Abilify and Nubain:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Abilify:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Nubain:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Abilify and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nubain and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on aripiprazole and nalbuphine hydrochloride (the active ingredients of Abilify and Nubain, respectively), and Abilify and Nubain (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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