Abilify and Ondansetron hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Abilify (aripiprazole) and Ondansetron hydrochloride (ondansetron hydrochloride). Common drug interactions include cough among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Abilify and Ondansetron hydrochloride. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,454 Abilify users. Check the latest studies of Abilify.

What is Ondansetron hydrochloride?

Ondansetron hydrochloride has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 11,498 Ondansetron hydrochloride users. Check the latest studies of Ondansetron hydrochloride.



On Jul, 13, 2026

77 people who take Abilify and Ondansetron hydrochloride together, and have interactions are studied.

Abilify and Ondansetron hydrochloride drug interactions.

What are the common drug interactions of Abilify and Ondansetron Hydrochloride, by gender? *:

female:

  1. Cough
  2. Death
  3. Disability
  4. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  5. Dyspnoea (difficult or laboured respiration)
  6. Glomerular filtration rate decreased
  7. Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
  8. Haemorrhage (bleeding)
  9. Hallucination (an experience involving the perception of something not present)
  10. Hyperglycaemia (high blood sugar)

male:

  1. Abdominal discomfort
  2. Diarrhoea
  3. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  4. Muscle rigidity (muscle stiffness)
  5. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  6. Suicidal ideation
  7. Asthenia (weakness)
  8. Balance disorder
  9. Blood potassium decreased
  10. Constipation

What are the common drug interactions of Abilify and Ondansetron Hydrochloride, by age (0-1 to 60+)? *:

0-1:

  1. Respiratory tract infection
  2. Suicide attempt

2-9:

n/a

10-19:

n/a

20-29:

  1. Abdominal discomfort
  2. Diarrhoea
  3. Neuralgia (pain in one or more nerves)
  4. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  5. Muscle spasms (muscle contraction)
  6. Energy increased
  7. Therapeutic response unexpected
  8. Muscle rigidity (muscle stiffness)
  9. Pulmonary embolism (blockage of the main artery of the lung)
  10. Suicidal ideation

30-39:

  1. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  2. Weight decreased
  3. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  4. Vitamin d deficiency
  5. Abdominal discomfort
  6. Arthralgia (joint pain)
  7. Back disorder
  8. Blood pressure decreased
  9. Drug ineffective
  10. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

40-49:

  1. Chronic kidney disease
  2. Constipation
  3. Renal failure (kidney dysfunction)
  4. Asthma exercise induced
  5. Blood glucose decreased
  6. Blood sodium decreased
  7. Blood urine present
  8. Disability
  9. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  10. Glomerular filtration rate decreased

50-59:

  1. Pneumonia
  2. Poor quality sleep
  3. Pruritus (severe itching of the skin)
  4. Psychological trauma
  5. Sacral pain (pain at sacrum bone region)
  6. Sinus headache (headache caused by sinus infections)
  7. Sinusitis (inflammation of sinus)
  8. Skin infection
  9. Somnolence (a state of near-sleep, a strong desire for sleep)
  10. Spinal stenosis (narrowing of spinal column)

60+:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Death
  4. Drug ineffective
  5. Dysarthria (speech disorder)
  6. Eye swelling
  7. Fatigue (feeling of tiredness)
  8. Fungal infection
  9. Gastrointestinal viral infection (virus infection of gastrointestinal tract)
  10. Haemoglobin decreased

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 25 people, 32.47%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 16.88%
  3. Pain: 12 people, 15.58%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 12.99%
  5. High Blood Pressure: 9 people, 11.69%
  6. High Blood Cholesterol: 9 people, 11.69%
  7. Drowsiness: 8 people, 10.39%
  8. Infection: 6 people, 7.79%
  9. Indigestion: 6 people, 7.79%
  10. Stress And Anxiety: 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Abilify and Ondansetron hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Abilify:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ondansetron hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Abilify and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ondansetron hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on aripiprazole and ondansetron hydrochloride (the active ingredients of Abilify and Ondansetron hydrochloride, respectively), and Abilify and Ondansetron hydrochloride (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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