Abilify and Treximet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Abilify (aripiprazole) and Treximet (naproxen sodium; sumatriptan succinate). Common drug interactions include anxiety among females.

The phase IV clinical study analyzes what interactions people have when they take Abilify and Treximet. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,456 Abilify users. Check the latest studies of Abilify.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12 people who take Abilify and Treximet together, and have interactions are studied.

What are the common drug interactions of Abilify and Treximet, by gender? *:

female:

Anxiety
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Burning sensation
Chronic kidney disease
Disturbance in attention
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Headache (pain in head)
Heart rate increased
Hot flush (sudden feelings of heat)

male:

n/a

What are the common drug interactions of Abilify and Treximet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Gallbladder disorder
Organ failure
Dry mouth
Dyskinesia (abnormality or impairment of voluntary movement)
Injury
Pain
Salivary hypersecretion (excess saliva secretion)

30-39:

n/a

40-49:

Abdominal discomfort
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Burning sensation
Diarrhoea
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate increased
Malaise (a feeling of general discomfort or uneasiness)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)

50-59:

Hot flush (sudden feelings of heat)
Lacrimation increased
Insomnia (sleeplessness)
Anxiety
Diarrhoea
Disturbance in attention
Drug ineffective
Fatigue (feeling of tiredness)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 25.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 25.00%
Amenorrhea (absence of a menstrual period in a woman of reproductive age): 2 people, 16.67%
Bipolar Disorder (mood disorder): 2 people, 16.67%
Osteoporosis (bones weak and more likely to break): 2 people, 16.67%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 8.33%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 8.33%
Birth Control: 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%
Thyroid Diseases: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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