Abilify and Unasyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Abilify (aripiprazole) and Unasyn (ampicillin sodium; sulbactam sodium). Common drug interactions include dysphagia among females and pneumonia aspiration among males.

The phase IV clinical study analyzes what interactions people have when they take Abilify and Unasyn. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,456 Abilify users. Check the latest studies of Abilify.

What is Unasyn?

Unasyn has active ingredients of ampicillin sodium; sulbactam sodium. eHealthMe is studying from 4,474 Unasyn users. Check the latest studies of Unasyn.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

35 people who take Abilify and Unasyn together, and have interactions are studied.

What are the common drug interactions of Abilify and Unasyn, by gender? *:

female:

Dysphagia (a condition in which swallowing is difficult or painful)
Eating disorder
Electrocardiogram qt prolonged
Epicondylitis (tennis elbow)
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Gingival bleeding (bleeding gums)
Gingival erosion (gum ulcer)

male:

Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Agitation (state of anxiety or nervous excitement)
Cellulitis (infection under the skin)
Chest pain
Cholecystitis acute (rapid infection of gallbladder)
Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Drug abuse
Gastroenteritis (inflammation of stomach and intestine)

What are the common drug interactions of Abilify and Unasyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Tonic convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it)

30-39:

Abdominal pain
Abdominal pain lower
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Chest pain
Cholecystitis acute (rapid infection of gallbladder)
Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

40-49:

Agitation (state of anxiety or nervous excitement)
Hyperthermia (body temperature greatly above normal)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Nephrogenic diabetes insipidus (a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine)
Overdose
Abdominal pain
Anogenital warts
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Drug level decreased
Enteritis (inflammation of the small intestine)

50-59:

Abdominal pain
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Arteriosclerosis (thickening and hardening of arteries)
Asthma
Blood pressure decreased
Blood pressure increased
Cardiac failure
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort

60+:

Chest pain
Fall
Spinal column injury (spinal cord bone injury)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Laceration (tearing of soft body tissue)
Dysphagia (a condition in which swallowing is difficult or painful)
Joint swelling
Abscess jaw (tooth abscess or root abscess)
Aggression
Anaemia (lack of blood)

What are the existing conditions these people have? *

Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 7 people, 20.00%
Agitation (state of anxiety or nervous excitement): 6 people, 17.14%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 14.29%
Diabetes Insipidus - Nephrogenic (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 5 people, 14.29%
Infection: 4 people, 11.43%
Pain: 3 people, 8.57%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 8.57%
Sleep Disorder: 2 people, 5.71%
Persecutory Delusion: 2 people, 5.71%
Osteoporosis (bones weak and more likely to break): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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