Accolate and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accolate (zafirlukast) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include chest discomfort among females and aphonia among males.

The phase IV clinical study analyzes what interactions people have when they take Accolate and Tylenol w/ codeine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Accolate?

Accolate has active ingredients of zafirlukast. It is often used in asthma. eHealthMe is studying from 4,220 Accolate users. Check the latest studies of Accolate.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

On Jul, 08, 2026

22 people who take Accolate and Tylenol w/ codeine together, and have interactions are studied.

Accolate and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Accolate and Tylenol W/ Codeine, by gender? *:

female:

Chest discomfort
Cough
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Headache (pain in head)
Injection site urticaria (rash of round, red welts on the skin at injection site)
Intervertebral disc degeneration (spinal disc degeneration)
Syncope (loss of consciousness with an inability to maintain postural tone)
Albumin urine present
Diarrhoea haemorrhagic (bloody diarrhoea)
Fibrin d dimer increased

male:

Aphonia (inability to produce voice)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Renal cell carcinoma stage unspecified (kidney cancer in unknown stage)
Clamminess (moist, sticky, and cold to the touch)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Dry mouth
Dry throat
Fungal infection
Gastro-oesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hoarseness (changing voice)

What are the common drug interactions of Accolate and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaphylactic reaction (serious allergic reaction)
Dyspnoea (difficult or laboured respiration)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Injection site urticaria (rash of round, red welts on the skin at injection site)
Syncope (loss of consciousness with an inability to maintain postural tone)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Nausea (feeling of having an urge to vomit)

40-49:

Cataract (clouding of the lens inside the eye)

50-59:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Overdose
Spinal column stenosis (narrowing of spinal column)
Spinal disorder (disease of spine a back bone)
Cyst (a closed sac)
Hypergammaglobulinaemia benign monoclonal (elevated levels of gamma globulin)
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Ligament disorder (disease of ligament)
Ligament laxity (loose ligaments)

60+:

Fungal infection
Nausea (feeling of having an urge to vomit)
Confusional state
Dementia (madness)
Depression
Diabetes mellitus inadequate control
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Gastroenteritis (inflammation of stomach and intestine)
Lethargy (tiredness)

* Approximation only. Some reports may have incomplete information.

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