Midol and Indigestion - a phase IV clinical study of FDA data

Summary:

Indigestion is reported as a side effect among people who take Midol (ibuprofen), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Advair Diskus 100/50, and have Pelvic pain.

The phase IV clinical study analyzes which people have Indigestion when taking Midol. It is created by eHealthMe based on reports of 2,307 people who have side effects when taking Midol from the FDA, and is updated regularly.

What is Midol?

Midol has active ingredients of ibuprofen. It is often used in painful menstrual periods. eHealthMe is studying from 2,635 Midol users. Check the latest studies of Midol.

What is Indigestion?

Indigestion is found to be associated with 2,431 drugs and 3,410 conditions by eHealthMe. Check the latest studies of Indigestion.



On Jul, 08, 2026

2,307 people reported to have side effects when taking Midol.
Among them, 22 people (0.95%) have Indigestion.

Could Midol cause Indigestion?

Among these 22 people:

How long have people been on Midol when they have Indigestion? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Indigestion when taking Midol? *

  • female: 90 %
  • male: 10 %

What is the age of people who have Indigestion when taking Midol? *

  • 0-1: 0.0 %
  • 2-9: 5.56 %
  • 10-19: 27.78 %
  • 20-29: 16.67 %
  • 30-39: 16.67 %
  • 40-49: 33.33 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Midol? *

  1. Proair Hfa: 3 people, 13.64%
  2. Ibuprofen: 3 people, 13.64%
  3. Augmentin '125': 3 people, 13.64%
  4. Advair Diskus 100/50: 3 people, 13.64%
  5. Yaz: 2 people, 9.09%
  6. Hydrocodone Bitartrate And Acetaminophen: 2 people, 9.09%
  7. Seroquel: 1 person, 4.55%
  8. Reglan: 1 person, 4.55%
  9. Protonix: 1 person, 4.55%
  10. Plan B One-Step: 1 person, 4.55%

What are other side effects people have besides Indigestion? *

  1. Abdominal Pain Upper: 7 people, 31.82%
  2. Nausea (feeling of having an urge to vomit): 7 people, 31.82%
  3. Gallbladder Disease: 4 people, 18.18%
  4. Biliary Dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi): 4 people, 18.18%
  5. Nausea And Vomiting: 4 people, 18.18%
  6. Chest Pain: 3 people, 13.64%
  7. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 13.64%
  8. Hepatobiliary Scan Abnormal: 3 people, 13.64%
  9. Cholecystitis Chronic (long lasting infection of gallbladder): 3 people, 13.64%
  10. Hypoaesthesia (reduced sense of touch or sensation): 2 people, 9.09%

What are the existing conditions these people have? *

  1. Pelvic Pain: 3 people, 13.64%
  2. Muscle Spasms (muscle contraction): 2 people, 9.09%
  3. Back Pain: 2 people, 9.09%
  4. Stress And Anxiety: 1 person, 4.55%
  5. Panic Disorder: 1 person, 4.55%
  6. Heavy Or Prolong Menstrual Bleeding: 1 person, 4.55%
  7. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 4.55%
  8. Abdominal Pain: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Midol and have Indigestion?

- Check whether Indigestion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Midol:

Indigestion treatments and more:

How severe was Indigestion and when was it recovered:

Expand to all the drugs that have ingredients of ibuprofen:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Midol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Indigestion:

Browse all the conditions that are associated with Indigestion:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Midol) and Midol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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