Accupril and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accupril (quinapril hydrochloride) and Diphen (diphenhydramine hydrochloride). Common drug interactions include atypical pneumonia among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Accupril and Diphen. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Accupril?

Accupril has active ingredients of quinapril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,404 Accupril users. Check the latest studies of Accupril.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

80 people who take Accupril and Diphen together, and have interactions are studied.

What are the common drug interactions of Accupril and Diphen, by gender? *:

female:

Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Breast disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Flushing (the warm, red condition of human skin)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Dyspnoea (difficult or laboured respiration)
Ill-defined disorder
Pain
Breast cancer recurrent
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

male:

Arrhythmia (irregular heartbeat)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Hepatic failure (liver failure)
Liver disorder (liver diseases)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pneumonia

What are the common drug interactions of Accupril and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Type 2 diabetes mellitus

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Attention deficit/hyperactivity disorder
Chest discomfort
Depression
Ear pain
Facial pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Oropharyngeal pain
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

50-59:

Renal failure (kidney dysfunction)
Thrombosis (formation of a blood clot inside a blood vessel)
Aortic thrombosis (formation of a blood clot inside aorta)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Anxiety
Dehydration (dryness resulting from the removal of water)
Depression
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Iga nephropathy (kidney disease- condition prevents the kidneys from filtering waste)

60+:

Muscle spasms (muscle contraction)
Arthralgia (joint pain)
Heart rate increased
Hypotension (abnormally low blood pressure)
Infusion related reaction
Blood pressure fluctuation
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Breast disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 36 people, 45.00%
Breast Cancer: 16 people, 20.00%
Immunodeficiency Common Variable: 15 people, 18.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 13.75%
Pain: 8 people, 10.00%
Stress And Anxiety: 7 people, 8.75%
Primary Immunodeficiency Syndrome: 7 people, 8.75%
Itching: 6 people, 7.50%
Constipation: 6 people, 7.50%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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