Clonidine and Nitro-dur drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonidine (clonidine) and Nitro-dur (nitroglycerin). Common drug interactions include chronic kidney disease among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Clonidine and Nitro-dur. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,645 Clonidine users. Check the latest studies of Clonidine.

What is Nitro-dur?

Nitro-dur has active ingredients of nitroglycerin. eHealthMe is studying from 2,414 Nitro-dur users. Check the latest studies of Nitro-dur.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 03, 2026

36 people who take Clonidine and Nitro-dur together, and have interactions are studied.

Clonidine and Nitro-dur drug interactions.

What are the common drug interactions of Clonidine and Nitro-Dur, by gender? *:

female:

  1. Chronic kidney disease
  2. Coagulopathy (blood's ability to clot is impaired)
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  4. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  5. Coronary artery stenosis (narrowing of coronary artery)
  6. Decreased appetite
  7. Decreased immune responsiveness
  8. Deformity (disfigurement)
  9. Dehydration (dryness resulting from the removal of water)
  10. Depression

male:

  1. Diarrhoea
  2. Fatigue (feeling of tiredness)
  3. Asthenia (weakness)
  4. Blood glucose decreased
  5. Blood iron decreased
  6. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  7. Chest pain
  8. Coagulopathy (blood's ability to clot is impaired)
  9. Decreased appetite
  10. Drug ineffective

What are the common drug interactions of Clonidine and Nitro-Dur, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Chest pain
  2. Drug administration error
  3. Gait disturbance
  4. Memory impairment
  5. Oedema (fluid collection in tissue)
  6. Oedema mouth (swelling of mouth)
  7. Renal failure acute (rapid kidney dysfunction)
  8. Speech disorder
  9. Urticaria (rash of round, red welts on the skin that itch intensely)
  10. Cerebral disorder (brain disease)

50-59:

  1. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
  2. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  3. Chest pain
  4. Diarrhoea
  5. Ear infection
  6. Gastritis (inflammation of stomach)
  7. Haematuria (presence of blood in urine)
  8. Headache (pain in head)

60+:

  1. Bradycardia (abnormally slow heart action)
  2. Nausea (feeling of having an urge to vomit)
  3. Ocular hypertension (intraocular pressure higher than normal)
  4. Pain
  5. Fall
  6. Anxiety
  7. Atrioventricular block first degree (heart block first degree)
  8. Back pain
  9. Coagulopathy (blood's ability to clot is impaired)
  10. Confusional state

What are the existing conditions these people have? *

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 16.67%
  2. Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 4 people, 11.11%
  3. Stable Angina (a constant chest pain): 3 people, 8.33%
  4. Constipation: 3 people, 8.33%
  5. Pain: 2 people, 5.56%
  6. Immunodeficiency Common Variable: 2 people, 5.56%
  7. Diabetes: 2 people, 5.56%
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Clonidine and Nitro-dur:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Nitro-dur:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clonidine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nitro-dur and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on clonidine and nitroglycerin (the active ingredients of Clonidine and Nitro-dur, respectively), and Clonidine and Nitro-dur (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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