Accutane and Azithromycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accutane (isotretinoin) and Azithromycin (azithromycin). Common drug interactions include chondropathy among females and dry skin among males.

The phase IV clinical study analyzes what interactions people have when they take Accutane and Azithromycin. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

What is Azithromycin?

Azithromycin has active ingredients of azithromycin. It is often used in sinusitis. eHealthMe is studying from 40,716 Azithromycin users. Check the latest studies of Azithromycin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

25 people who take Accutane and Azithromycin together, and have interactions are studied.

Accutane and Azithromycin drug interactions.

What are the common drug interactions of Accutane and Azithromycin, by gender? *:

female:

Chondropathy (disease of the cartilage)
Chondrosis (softening or loss of smooth cartilage)
Chorioretinitis (an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina of the eye)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Colitis (inflammation of colon)
Constipation
Cyst (a closed sac)
Decreased appetite
Diarrhoea

male:

Dry skin
Headache (pain in head)
Suicidal ideation
Pneumonia
Arthralgia (joint pain)
Blood triglycerides increased
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Cyst (a closed sac)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dry eye (lack of adequate tears)

What are the common drug interactions of Accutane and Azithromycin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Menstrual disorder (disease of menstrual cycle)
Colitis ulcerative (inflammation of colon with ulcer)
Dry skin
Blood pressure increased
Depression
Gout (uric acid crystals building up in the body)
Headache (pain in head)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Inflammatory bowel disease

20-29:

Inflammatory bowel disease
Depression
Emotional distress
Abdominal pain
Colitis ulcerative (inflammation of colon with ulcer)
Cholecystitis chronic (long lasting infection of gallbladder)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Intestinal obstruction
Anal fissure
Arthralgia (joint pain)

30-39:

Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Neck pain
Neoplasm progression (growth of tumour)
Oral pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)
Osteoporosis (bones weak and more likely to break)
Osteosclerosis (an elevation in bone density)

40-49:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dry eye (lack of adequate tears)
Dry skin
Emotional distress
Epistaxis (bleed from the nose)
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Irritable bowel syndrome
Lip dry
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))

50-59:

n/a

60+:

Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Depression
Inflammatory bowel disease
Injury
Drug ineffective
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 5 people, 20.00%
Muscle Spasms (muscle contraction): 5 people, 20.00%
Birth Control: 5 people, 20.00%
Menstruation Irregular: 3 people, 12.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 8.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 8.00%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 8.00%
Asthma: 2 people, 8.00%
Abdominal Pain: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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