Accutane and Decadron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accutane (isotretinoin) and Decadron (dexamethasone). Common drug interactions include back pain among females and inflammatory bowel disease among males.

The phase IV clinical study analyzes what interactions people have when they take Accutane and Decadron. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

What is Decadron?

Decadron has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 47,210 Decadron users. Check the latest studies of Decadron.



On Aug, 06, 2026

73 people who take Accutane and Decadron together, and have interactions are studied.

Accutane and Decadron drug interactions.

What are the common drug interactions of Accutane and Decadron, by gender? *:

female:

  1. Back pain
  2. Epistaxis (bleed from the nose)
  3. Pneumonia
  4. Asteatosis (any disease that persistently causes the skin to dry)
  5. Cheilitis (infection of lips)
  6. Colitis (inflammation of colon)
  7. Dry eye (lack of adequate tears)
  8. Dyspepsia (indigestion)
  9. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
  10. Folliculitis (infection of hair root)

male:

  1. Inflammatory bowel disease
  2. Colitis ulcerative (inflammation of colon with ulcer)
  3. Abscess (pus)
  4. Iron deficiency anaemia
  5. Stomach discomfort (pain in abdomen)
  6. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  7. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  8. Anxiety
  9. Eosinophilia (eosinophil count in the peripheral blood exceeds)
  10. Alanine aminotransferase increased

What are the common drug interactions of Accutane and Decadron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Colitis (inflammation of colon)
  2. Colitis ulcerative (inflammation of colon with ulcer)
  3. Inflammatory bowel disease
  4. Proctitis (inflammation of the rectum and anus)
  5. Anxiety
  6. Folliculitis (infection of hair root)
  7. Asteatosis (any disease that persistently causes the skin to dry)
  8. Back pain
  9. Cheilitis (infection of lips)
  10. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

20-29:

  1. Proctitis ulcerative (inflammation of the rectum and anus ulcerative)
  2. Stress
  3. Inflammatory bowel disease
  4. Irritable bowel syndrome
  5. Alopecia (absence of hair from areas of the body)
  6. Asthenia (weakness)
  7. Bone marrow failure
  8. Confusional state
  9. Death
  10. Decreased appetite

30-39:

  1. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  2. Respiratory failure (excl neonatal) (inadequate gas exchange by the respiratory system(excluding neonatal))
  3. Acidosis (build-up of carbon dioxide in the blood)
  4. Anxiety
  5. Blood creatinine increased
  6. Colitis ulcerative (inflammation of colon with ulcer)
  7. Colonic polyp (extra part of colon tissue grow in intestine)
  8. Decreased appetite
  9. Depression
  10. Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)

40-49:

n/a

50-59:

  1. Inflammatory bowel disease
  2. Depression
  3. Colitis ulcerative (inflammation of colon with ulcer)
  4. Injury
  5. Anxiety
  6. Proctitis (inflammation of the rectum and anus)
  7. Rectal polyp (fleshy growth occurring on the lining of the colon)
  8. Cheilitis (infection of lips)
  9. Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
  10. Irritable bowel syndrome

60+:

  1. Inflammatory bowel disease
  2. Colitis ulcerative (inflammation of colon with ulcer)
  3. Oral surgery
  4. Osteonecrosis (death of bone)
  5. Tooth extraction
  6. Weight decreased
  7. Attention deficit/hyperactivity disorder
  8. Bipolar disorder (mood disorder)
  9. Blood pressure decreased
  10. Blood triglycerides increased

What are the existing conditions these people have? *

  1. Lip Disorder (disease of lip): 14 people, 19.18%
  2. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 14 people, 19.18%
  3. Asteatosis (any disease that persistently causes the skin to dry): 14 people, 19.18%
  4. Brain Neoplasm Malignant (brain cancer tumour): 7 people, 9.59%
  5. Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 6 people, 8.22%
  6. Folliculitis (infection of hair root): 6 people, 8.22%
  7. Headache (pain in head): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Accutane and Decadron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Accutane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Decadron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Accutane and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Decadron and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin and dexamethasone (the active ingredients of Accutane and Decadron, respectively), and Accutane and Decadron (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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