Accutane and Dexedrine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accutane (isotretinoin) and Dexedrine (dextroamphetamine sulfate). Common drug interactions include nephrolithiasis among females and inflammatory bowel disease among males.

The phase IV clinical study analyzes what interactions people have when they take Accutane and Dexedrine. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

What is Dexedrine?

Dexedrine has active ingredients of dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,735 Dexedrine users. Check the latest studies of Dexedrine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

33 people who take Accutane and Dexedrine together, and have interactions are studied.

Accutane and Dexedrine drug interactions.

What are the common drug interactions of Accutane and Dexedrine, by gender? *:

female:

Nephrolithiasis (calculi in the kidneys)
Osteoporosis (bones weak and more likely to break)
Lip dry
Vomiting
White blood cell count decreased
Gastrointestinal hypomotility (less activity of the intestinal tract)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Abdominal pain
Back pain
Blood cholesterol increased

male:

Inflammatory bowel disease
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Ill-defined disorder
Intestinal haemorrhage (bleeding from intestine)
Multi-organ disorder (multiple organ disease)
Nasal dryness (dry nose)
Rectal haemorrhage (bleeding from anus)
Perirectal abscess
Lymphadenitis (inflammation or enlargement of a lymph node)
Pruritus ani (chronic itching of the skin around the anus)

What are the common drug interactions of Accutane and Dexedrine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Granuloma (a small area of inflammation due to tissue injury)
Headache (pain in head)
Intussusception
Sunburn
Upper respiratory tract infection
Vomiting
Abdominal abscess (collection of pus in abdomen)
Abdominal pain
Appendix disorder
Arthralgia (joint pain)

20-29:

Aggression
Anxiety
Bipolar disorder (mood disorder)
Electrocardiogram abnormal
Fatigue (feeling of tiredness)
Mood disorder (a condition characterized by distorted, excessive or inappropriate moods or emotions)
Psychotic disorder
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Suicidal ideation
Suicide attempt

30-39:

Arthralgia (joint pain)
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Inflammatory bowel disease
Intestinal haemorrhage (bleeding from intestine)
Intestinal obstruction
Irritable bowel syndrome
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nephrolithiasis (calculi in the kidneys)
Osteoporosis (bones weak and more likely to break)

40-49:

Blood cholesterol increased
Herpes simplex (herpes simplex is a common viral infection)
Mouth ulceration (mouth ulcers)
Arthralgia (joint pain)
Lip dry
White blood cell count decreased

50-59:

n/a

60+:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Arthralgia (joint pain)
Dry skin
Epistaxis (bleed from the nose)
Gastrointestinal hypomotility (less activity of the intestinal tract)
Intestinal obstruction
Lip dry

What are the existing conditions these people have? *

Depression: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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