Acetazolamide and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetazolamide (acetazolamide) and Aldactone (spironolactone). Common drug interactions include pituitary tumour among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Acetazolamide and Aldactone. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 08, 2026

64 people who take Acetazolamide and Aldactone together, and have interactions are studied.

Acetazolamide and Aldactone drug interactions.

What are the common drug interactions of Acetazolamide and Aldactone, by gender? *:

female:

Pituitary tumour
Renal failure (kidney dysfunction)
Hypokalaemia (low potassium)
Anaemia (lack of blood)
Constipation
Fatigue (feeling of tiredness)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Ileus (a painful obstruction of the ileum or other part of the intestine)

male:

Cardiac failure congestive
Haematoma (collection of blood outside the blood vessels)
Hepatic failure (liver failure)
Liver disorder (liver diseases)
Pneumonia
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Acetazolamide and Aldactone, by age (0-1 to 60+)? *:

0-1:

Bradycardia (abnormally slow heart action)
Hyperkalaemia (damage to or disease of the kidney)
Ventricular extrasystoles (premature cardiac contraction)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug hypersensitivity
Hepatic enzyme increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Allergy to chemicals
Blood alkaline phosphatase increased
Dehydration (dryness resulting from the removal of water)
Dizziness
Flushing (the warm, red condition of human skin)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypokalaemia (low potassium)

50-59:

Cerebellar ischaemia (lack of blood supply to cerebeller)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematoma (collection of blood outside the blood vessels)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hepatic failure (liver failure)
Liver disorder (liver diseases)
Pneumonia
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure acute (rapid kidney dysfunction)

60+:

Nausea (feeling of having an urge to vomit)
Vomiting
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Liver disorder (liver diseases)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

What are the existing conditions these people have? *

Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 8 people, 12.50%
Growth Hormone Deficiency: 8 people, 12.50%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 9.38%
Immune System Disorder: 6 people, 9.38%
Nausea (feeling of having an urge to vomit): 5 people, 7.81%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 6.25%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Acetazolamide and Aldactone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously