Acetazolamide and Primidone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetazolamide (acetazolamide) and Primidone (primidone). Common drug interactions include muscle contractions involuntary among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Acetazolamide and Primidone. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

On Aug, 07, 2026

56 people who take Acetazolamide and Primidone together, and have interactions are studied.

Acetazolamide and Primidone drug interactions.

What are the common drug interactions of Acetazolamide and Primidone, by gender? *:

female:

Muscle contractions involuntary (uncontrolled muscle contraction)
Muscle rigidity (muscle stiffness)
Neck pain
Oral discomfort (pain or irritation in mouth)
Parkinson's disease
Pruritus (severe itching of the skin)
Rash
Rehabilitation therapy
Resting tremor (an involuntary somewhat rhythmic, muscle contraction and relaxation during resting condition)
Restless legs syndrome (a powerful urge to move your legs)

male:

Drug ineffective
Anger
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Choreoathetosis (involuntary movement randomly from one part to another body part)
Drooling (drop saliva uncontrollably from the mouth)
Drug hypersensitivity
Dysphagia (a condition in which swallowing is difficult or painful)
Dystonia (abnormal muscle tone)
Eye swelling

What are the common drug interactions of Acetazolamide and Primidone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anticonvulsant drug level above therapeutic
Ataxia (loss of full control of bodily movements)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Choreoathetosis (involuntary movement randomly from one part to another body part)
Dystonia (abnormal muscle tone)

10-19:

Hypokalaemia (low potassium)
Abasia (inability to walk)
Agitation (state of anxiety or nervous excitement)
Anticonvulsant drug level increased
Diarrhoea
Drooling (drop saliva uncontrollably from the mouth)
Drug hypersensitivity
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Eye swelling

20-29:

n/a

30-39:

n/a

40-49:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Diarrhoea
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ataxia (loss of full control of bodily movements)
Balance disorder
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral atrophy (decrement in size of brain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Confusional state
Dysarthria (speech disorder)
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)

60+:

Cerebral haemorrhage (bleeding within the brain)
Dysphagia (a condition in which swallowing is difficult or painful)
Cataract (clouding of the lens inside the eye)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Eating disorder
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
Fall
Foot deformity (functional disability of foot)
Foot fracture

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 17 people, 30.36%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 19.64%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 11 people, 19.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 14.29%
Pain: 5 people, 8.93%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.14%
Body Temperature Increased: 4 people, 7.14%
Dyspnea (difficult or laboured breathing): 4 people, 7.14%
Aneurysm (enlargement of an artery caused by a weakening of the artery wall): 4 people, 7.14%
Headache (pain in head): 4 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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