Acetazolamide and Valacyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetazolamide (acetazolamide) and Valacyclovir (valacyclovir hydrochloride). Common drug interactions include injection site pain among females and allodynia among males.

The phase IV clinical study analyzes what interactions people have when they take Acetazolamide and Valacyclovir. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

On Jul, 06, 2026

59 people who take Acetazolamide and Valacyclovir together, and have interactions are studied.

Acetazolamide and Valacyclovir drug interactions.

What are the common drug interactions of Acetazolamide and Valacyclovir, by gender? *:

female:

Injection site pain
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
White blood cell count decreased
Chronic kidney disease
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Pain of skin
Therapeutic response decreased (less preventive response)
Urticaria (rash of round, red welts on the skin that itch intensely)
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)

male:

Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Anxiety
Hip fracture
Hypokinesia (decreased bodily movement)
Multiple fractures
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Renal injury (kidney injury)
Rib fracture

What are the common drug interactions of Acetazolamide and Valacyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Altered state of consciousness (altered state of mind)
Hydrocephalus (water on the brain)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Subdural haematoma (blood collects between the skull and the surface of the brain)

10-19:

Pain of skin
Therapeutic response decreased (less preventive response)
Urticaria (rash of round, red welts on the skin that itch intensely)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Enterococcal sepsis
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)

20-29:

Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Altered state of consciousness (altered state of mind)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Blood lactate dehydrogenase increased
Cardiac tamponade (fluid accumulates in heart covering)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cytomegalovirus infection
Cytomegalovirus test positive
Electrolyte imbalance

30-39:

Cerebral haemorrhage (bleeding within the brain)
Disease progression

40-49:

Cellulitis (infection under the skin)
Infection
Infusion site mass
Infusion site rash
Skin infection
Infusion site haematoma (localized swelling filled with blood at infusion site)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Weight increased
Sinusitis (inflammation of sinus)
Cystitis (inflammation of the wall of the bladder)

50-59:

Chronic kidney disease
Death
Nephrolithiasis (calculi in the kidneys)

60+:

Anxiety
Blood creatinine increased
Hypokinesia (decreased bodily movement)
Multiple fractures
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Renal injury (kidney injury)
Rib fracture
Thoracic vertebral fracture

What are the existing conditions these people have? *

Insomnia (sleeplessness): 7 people, 11.86%
Constipation: 6 people, 10.17%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 5 people, 8.47%
High Blood Pressure: 5 people, 8.47%
Pain: 4 people, 6.78%
Herpes Zoster: 4 people, 6.78%
Hereditary Angioedema (recurrent episodes of severe swelling): 4 people, 6.78%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 5.08%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 5.08%
Hiv Infection: 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

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