Ozempic and Advil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ozempic (semaglutide) and Advil (ibuprofen). Common drug interactions include fungal infection among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Ozempic and Advil. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,759 Ozempic users. Check the latest studies of Ozempic.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

On Jul, 06, 2026

37 people who take Ozempic and Advil together, and have interactions are studied.

What are the common drug interactions of Ozempic and Advil, by gender? *:

female:

Fungal infection
Gastric disorder (disease of stomach)
Glycosylated haemoglobin increased
Groin abscess (pus in groin)
Hyperchlorhydria (gastric acid levels are higher in stomach)
Hypersensitivity
Hypersomnia (excessive daytime sleepiness (eds))
Hypoxia (low oxygen in tissues)
Idiopathic pulmonary fibrosis (chronic lung disease)
Incontinence (lack of moderation or self-control)

male:

Nausea (feeling of having an urge to vomit)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Diarrhoea
Dry eye (lack of adequate tears)
Flatulence (flatus expelled through the anus)
Gait disturbance
Hospitalisation
Hot flush (sudden feelings of heat)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypertension (high blood pressure)

What are the common drug interactions of Ozempic and Advil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pain in extremity
Sunburn
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Poor venous access
Burning sensation
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Nasopharyngitis (inflammation of the nasopharynx)
Palpitations (feelings or sensations that your heart is pounding or racing)
Restless legs syndrome (a powerful urge to move your legs)
Sinus headache (headache caused by sinus infections)

50-59:

Nasal disorder (diseases of nose)
Nasal ulcer (ulcer of nose)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Palpitations (feelings or sensations that your heart is pounding or racing)
Postoperative thoracic procedure complication
Pyrexia (fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinus congestion (blockage of sinus)
Sinusitis (inflammation of sinus)
Speech disorder

60+:

Cough
Fatigue (feeling of tiredness)
Wheezing (a high-pitched whistling sound made while you breath)
Abdominal discomfort
Anxiety
Blood glucose decreased
Blood glucose fluctuation
Blood iron decreased
Cataract (clouding of the lens inside the eye)
Chest pain

What are the existing conditions these people have? *

Diabetes: 7 people, 18.92%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 16.22%
Headache (pain in head): 5 people, 13.51%
Type 2 Diabetes: 4 people, 10.81%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 4 people, 10.81%
Nausea (feeling of having an urge to vomit): 3 people, 8.11%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 5.41%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.41%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.41%
High Blood Pressure: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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