Acth and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acth (corticotropin) and Synthroid (levothyroxine sodium). Common drug interactions include feeling jittery among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Acth and Synthroid. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Acth?

Acth has active ingredients of corticotropin. eHealthMe is studying from 5,402 Acth users. Check the latest studies of Acth.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

On Jul, 14, 2026

93 people who take Acth and Synthroid together, and have interactions are studied.

What are the common drug interactions of Acth and Synthroid, by gender? *:

female:

Feeling jittery
Fluid retention (an abnormal accumulation of fluid in the blood)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Adverse drug reaction
Blood creatinine increased
Blood pressure increased
Decreased appetite
Escherichia infection (bacterial infection by escherichia coli)
Foot deformity (functional disability of foot)
Injection site discolouration

male:

Blood pressure increased
Fatigue (feeling of tiredness)
Chest discomfort
Chest pain
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fall
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Joint range of motion decreased (disease of joint movement)
Joint swelling
Osteonecrosis (death of bone)

What are the common drug interactions of Acth and Synthroid, by age (0-1 to 60+)? *:

0-1:

Bradycardia (abnormally slow heart action)

2-9:

n/a

10-19:

n/a

20-29:

Cardiac murmur (an heart sound in valve abnormality)
Dizziness
Loss of consciousness
Pallor
Tinnitus (a ringing in the ears)
Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

Chills (felling of cold)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Headache (pain in head)
Heart rate increased
Muscular weakness (muscle weakness)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Suicidal ideation

40-49:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Proteinuria (presence of protein in the urine)
Urine abnormality
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypokalaemia (low potassium)
Injection site bruising
Injection site discomfort
Injection site erythema (redness at injection site)

50-59:

Left ventricular dysfunction
Staphylococcal infection (an infection with staphylococcus bacteria)
Blood glucose increased
Feeling jittery
Swelling
Asthenia (weakness)
Heart rate increased
Abdominal distension
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug ineffective

60+:

Mouth injury
Stress
Gait disturbance
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Tooth loss
Blood glucose increased
Headache (pain in head)
Hypertension (high blood pressure)
Swelling
Adverse event

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 28 people, 30.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 11 people, 11.83%
Pain: 9 people, 9.68%
Nausea (feeling of having an urge to vomit): 9 people, 9.68%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 8 people, 8.60%
Asthma: 8 people, 8.60%
High Blood Pressure: 8 people, 8.60%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 7 people, 7.53%
Stress And Anxiety: 7 people, 7.53%
Joint Pain: 7 people, 7.53%

* Approximation only. Some reports may have incomplete information.

Do you take Acth and Synthroid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously