Acthar and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acthar (corticotropin) and Profen (ibuprofen). Common drug interactions include hypersensitivity among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Acthar and Profen. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Acthar?

Acthar has active ingredients of corticotropin. eHealthMe is studying from 4,948 Acthar users. Check the latest studies of Acthar.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

81 people who take Acthar and Profen together, and have interactions are studied.

What are the common drug interactions of Acthar and Profen, by gender? *:

female:

Hypersensitivity
Hyporeflexia (a condition of below normal or absent reflexes)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Oesophageal disorder (disease of oesophagus)
Panic disorder
Quality of life decreased
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Sensory disturbance (sense disturbance)
Swelling
Uterine disorder

male:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Injection site haemorrhage (bleeding from injection site)
Oxygen saturation decreased
Pulmonary hypertension (increase in blood pressure in the lung artery)
Weight decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pneumonia

What are the common drug interactions of Acthar and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Abdominal pain
Anxiety
Asthenia (weakness)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Depression
Fear
Gait disturbance
Grip strength decreased
Squamous cell carcinoma of the cervix (cervix cancer of a kind of epithelial cell)

30-39:

Asthenia (weakness)
Balance disorder
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gait disturbance
Headache (pain in head)
Fall
Muscular weakness (muscle weakness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

40-49:

Asthenia (weakness)
Balance disorder
Fall
Insomnia (sleeplessness)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle tightness
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Tachyphrenia (abnormally rapid mental activity)

50-59:

Therapeutic response unexpected
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vomiting
White blood cell count decreased
Injection site pruritus (severe itching at injection site)
Injection site rash
Abdominal discomfort
Abdominal pain
Adrenal mass
Affect lability (emotional incontinence)

60+:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Asthenia (weakness)
Adverse event
Dysphagia (a condition in which swallowing is difficult or painful)
Memory impairment
Muscular weakness (muscle weakness)
Oesophageal disorder (disease of oesophagus)
Panic disorder
Uterine disorder
Asthma

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 34 people, 41.98%
Gait Disturbance: 15 people, 18.52%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 7.41%
Pulmonary Sarcoidosis (growth of tiny collections of inflammatory cells in lungs): 5 people, 6.17%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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