Acticlate and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acticlate (doxycycline hyclate) and Synthroid (levothyroxine sodium). Common drug interactions include acne among females and tunnel vision among males.

The phase IV clinical study analyzes what interactions people have when they take Acticlate and Synthroid. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Acticlate?

Acticlate has active ingredients of doxycycline hyclate. eHealthMe is studying from 129 Acticlate users. Check the latest studies of Acticlate.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,202 Synthroid users. Check the latest studies of Synthroid.



On Aug, 06, 2026

11 people who take Acticlate and Synthroid together, and have interactions are studied.

Acticlate and Synthroid drug interactions.

What are the common drug interactions of Acticlate and Synthroid, by gender? *:

female:

  1. Acne (skin problems that cause pimples)
  2. Oral herpes (viral infection of mouth)
  3. Suicidal ideation
  4. Surgery
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Fatigue (feeling of tiredness)
  7. Herpes virus infection
  8. Hypersensitivity
  9. Insulin resistance
  10. Narcolepsy (brain's inability to regulate sleep-wake cycles normally)

male:

  1. Tunnel vision (the loss of peripheral vision with retention of central vision)

What are the common drug interactions of Acticlate and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Tooth discolouration (a change in colour of teeth)

40-49:

n/a

50-59:

  1. Acne (skin problems that cause pimples)
  2. Alopecia (absence of hair from areas of the body)
  3. Suicidal ideation
  4. Surgery
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Herpes virus infection
  7. Depression
  8. Impetigo (contagious skin infection)
  9. Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
  10. Peripheral coldness

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 63.64%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 63.64%
  3. Hair Loss: 3 people, 27.27%
  4. Gastric Ulcer (stomach ulcer): 3 people, 27.27%
  5. Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 27.27%
  6. Constipation: 3 people, 27.27%
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 27.27%
  8. Acne (skin problems that cause pimples): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Acticlate and Synthroid?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Acticlate and Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acticlate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Acticlate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Synthroid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate and levothyroxine sodium (the active ingredients of Acticlate and Synthroid, respectively), and Acticlate and Synthroid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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