Actigall and Folic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actigall (ursodiol) and Folic acid (folic acid). Common drug interactions include thrombocytopenia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Actigall and Folic acid. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

What is Folic acid?

Folic acid has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 165,025 Folic acid users. Check the latest studies of Folic acid.

On Jul, 11, 2026

80 people who take Actigall and Folic acid together, and have interactions are studied.

Actigall and Folic acid drug interactions.

What are the common drug interactions of Actigall and Folic Acid, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)
Cytomegalovirus antigen positive
Liver transplant
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal adhesions (inflammation of abdomen)
Anaemia (lack of blood)
Biliary cirrhosis (biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver)
Biliary tract disorder

male:

Pyrexia (fever)
Blood urea increased
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Oedema peripheral (superficial swelling)
Pain in extremity
Platelet count decreased
Skin hypertrophy (skin cells enlarges)
Abdominal pain
Anaemia (lack of blood)

What are the common drug interactions of Actigall and Folic Acid, by age (0-1 to 60+)? *:

0-1:

Abdominal adhesions (inflammation of abdomen)
Biliary cirrhosis (biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver)
Cerebral haematoma (collection of blood in brain)
Cerebral haemorrhage (bleeding within the brain)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Coagulopathy (blood's ability to clot is impaired)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypersensitivity
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

2-9:

n/a

10-19:

Biliary tract disorder
Cholangitis sclerosing (infection and obstruction of bile duct)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Vision blurred
Headache (pain in head)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Ileitis (inflammation of the ileum)

20-29:

Hepatic failure (liver failure)
Abdominal pain
Anaemia (lack of blood)
Anorectal varices haemorrhage (dilation of collateral submucousal vessels due to backflow in the veins of the rectum with massive bleeding)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blood lactic acid increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Coagulopathy (blood's ability to clot is impaired)
Contusion (a type of hematoma of tissue in which capillaries)

30-39:

Blood albumin decreased
Blood lactate dehydrogenase increased
Blood urea increased
Haemoglobin decreased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pericardial effusion (fluid around the heart)
Vasospasm (sudden constriction of a blood vessel, reducing its diameter and flow rate)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
White blood cell count decreased
Abdominal pain

40-49:

Intra-abdominal haemorrhage (intra-abdominal bleeding)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pyrexia (fever)
Paralysis
Spinal cord compression
Blood bilirubin increased
Cough
Cytomegalovirus antigen positive
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematocrit decreased

50-59:

Back disorder
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood alkaline phosphatase increased
Blood creatine increased
Blood glucose increased
Blood pressure decreased
Blood pressure increased
Blood urea increased
Burning sensation

60+:

Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)
Liver transplant
Vomiting
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Acute myocardial infarction (acute heart attack)
Acute respiratory failure
Anaemia (lack of blood)
Aortic valve replacement
Aortic valve stenosis (narrowing of the aortic valve)
Application site irritation

What are the existing conditions these people have? *

Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 8 people, 10.00%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 5 people, 6.25%
Anaemia (lack of blood): 5 people, 6.25%
Nausea (feeling of having an urge to vomit): 4 people, 5.00%
Immunodeficiency Disorders: 4 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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