Actimmune and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actimmune (interferon gamma-1b) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include gastrointestinal disorder among females and chills among males.

The phase IV clinical study analyzes what interactions people have when they take Actimmune and Benadryl. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Actimmune?

Actimmune has active ingredients of interferon gamma-1b. eHealthMe is studying from 1,734 Actimmune users. Check the latest studies of Actimmune.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

24 people who take Actimmune and Benadryl together, and have interactions are studied.

Actimmune and Benadryl drug interactions.

What are the common drug interactions of Actimmune and Benadryl, by gender? *:

female:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Lung neoplasm (tumour of lung)
Lung nodule (solid, raised areas in lung)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Night sweats (sweating in night)
Overdose
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)

male:

Chills (felling of cold)
Dyspnoea (difficult or laboured respiration)
Asthenia (weakness)
Bradycardia (abnormally slow heart action)
Burning sensation
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic granulomatous disease (immune system cells are unable to kill some types of bacteria and fungi)
Coma (state of unconsciousness lasting more than six hours)
Cough

What are the common drug interactions of Actimmune and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Burning sensation
Pain
Pyrexia (fever)

20-29:

Arthralgia (joint pain)
Bone pain
Breast abscess
Headache (pain in head)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Swollen tongue (swelling of tongue)

30-39:

Chronic granulomatous disease (immune system cells are unable to kill some types of bacteria and fungi)
Headache (pain in head)

40-49:

Subcutaneous abscess
Transferrin decreased
Unwanted awareness during anaesthesia
White blood cell count decreased
Bone pain
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Night sweats (sweating in night)
Overdose
Red blood cell sedimentation rate increased
Pyrexia (fever)

50-59:

Ascites (accumulation of fluid in the abdominal cavity)
Biliary colic
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Renal failure (kidney dysfunction)
Weight decreased
Asthenia (weakness)
Bradycardia (abnormally slow heart action)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coma (state of unconsciousness lasting more than six hours)

60+:

Pyrexia (fever)
Ammonia increased
Dyspnoea exertional (breathlessness or shortness of breath)
Heart rate increased
Pneumonia
Rigors (an episode of shaking or exaggerated shivering)
Anaemia (lack of blood)
Blood potassium abnormal
Blood pressure decreased
Cardiac failure congestive

What are the existing conditions these people have? *

Chronic Granulomatous Disease (immune system cells are unable to kill some types of bacteria and fungi): 6 people, 25.00%
Ovarian Cancer (cancer of ovary): 5 people, 20.83%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 8.33%
Hepatitis C: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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