Actiq and Allegra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actiq (fentanyl citrate) and Allegra (fexofenadine hydrochloride). Common drug interactions include ejection fraction decreased among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Actiq and Allegra. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Actiq?

Actiq has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 27,583 Actiq users. Check the latest studies of Actiq.

What is Allegra?

Allegra has active ingredients of fexofenadine hydrochloride. It is often used in allergies. eHealthMe is studying from 75,498 Allegra users. Check the latest studies of Allegra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

34 people who take Actiq and Allegra together, and have interactions are studied.

What are the common drug interactions of Actiq and Allegra, by gender? *:

female:

Ejection fraction decreased (systolic heart failure)
Febrile neutropenia (fever with reduced white blood cells)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Back pain
Asthenia (weakness)
Dry mouth
Dysarthria (speech disorder)
Gingival infection (gum infection)

male:

Diarrhoea
Aspartate aminotransferase increased
Neuromyopathy (disease of both muscles and nerves)
Anger
Colitis (inflammation of colon)
Decreased appetite
Drug tolerance increased
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Irritability
Learning disability (difficulty in learning)

What are the common drug interactions of Actiq and Allegra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain lower
Back pain
Post procedural discomfort
Post procedural haemorrhage (post procedural bleeding)
Procedural pain
Uterine rupture

40-49:

Diarrhoea
Aspartate aminotransferase increased
Hypokalaemia (low potassium)
Liver carcinoma ruptured (ruptured liver cancer tumour)
Abdominal pain
Hepatic failure (liver failure)
Myopathy (a muscular disease in which the muscle fibres do not function)
Neuromyopathy (disease of both muscles and nerves)

50-59:

Decreased appetite
Drug dependence
Drug tolerance increased
Insomnia (sleeplessness)
Irritability
Learning disability (difficulty in learning)
Lethargy (tiredness)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Road traffic accident
Back pain

60+:

Ejection fraction decreased (systolic heart failure)
Febrile neutropenia (fever with reduced white blood cells)
Chest discomfort
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Glomerulonephritis (a group of conditions that affect parts of the kidneys called glomeruli)
Headache (pain in head)
Inflammation
Insomnia (sleeplessness)
Lip swelling
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)

What are the existing conditions these people have? *

Abdominal Pain: 14 people, 41.18%
Nausea (feeling of having an urge to vomit): 14 people, 41.18%
Headache (pain in head): 12 people, 35.29%
Hepatic Neoplasm Malignant (liver cancer): 12 people, 35.29%
Hepatitis B: 12 people, 35.29%
High Blood Pressure: 12 people, 35.29%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 12 people, 35.29%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 10 people, 29.41%
Itching: 9 people, 26.47%
Oesophagitis (inflammation of oesophagus): 8 people, 23.53%

* Approximation only. Some reports may have incomplete information.

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