Actiq and Fluoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actiq (fentanyl citrate) and Fluoxetine (fluoxetine hydrochloride). Common drug interactions include cellulitis among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Actiq and Fluoxetine. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Actiq?

Actiq has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 27,583 Actiq users. Check the latest studies of Actiq.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

On Jul, 09, 2026

35 people who take Actiq and Fluoxetine together, and have interactions are studied.

What are the common drug interactions of Actiq and Fluoxetine, by gender? *:

female:

Cellulitis (infection under the skin)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug ineffective
Drug toxicity
Electrocardiogram qt prolonged
Nephrolithiasis (calculi in the kidneys)
Ovarian cyst (fluid filled sac of the ovary)
Pruritus (severe itching of the skin)
Diabetic foot
Diarrhoea

male:

Arthralgia (joint pain)
Discomfort
Intervertebral disc degeneration (spinal disc degeneration)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Arthropathy
Haematochezia (passage of stools containing blood)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Post laminectomy syndrome
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)

What are the common drug interactions of Actiq and Fluoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain lower
Back pain
Post procedural discomfort
Post procedural haemorrhage (post procedural bleeding)
Procedural pain
Uterine rupture

40-49:

Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Nephrolithiasis (calculi in the kidneys)
Oedema peripheral (superficial swelling)
Ovarian cyst (fluid filled sac of the ovary)
Pruritus (severe itching of the skin)
Diabetic foot
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Fungal infection

50-59:

Hypophagia (reduced food intake)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Arthropathy
Haematochezia (passage of stools containing blood)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Post laminectomy syndrome
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)

60+:

Oedema peripheral (superficial swelling)
Death

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 15 people, 42.86%
Birth Control: 4 people, 11.43%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 8.57%
Stress And Anxiety: 2 people, 5.71%
Neuralgia (pain in one or more nerves): 2 people, 5.71%
Multiple Allergies (allergy to multiple agents): 2 people, 5.71%
High Blood Pressure: 2 people, 5.71%
Diabetes: 2 people, 5.71%
Coronary Artery Insufficiency (insufficiency of artery to carry blood to heart): 2 people, 5.71%
Chest Pain: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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