Retin-a and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Retin-a (tretinoin) and Methotrexate (methotrexate sodium). Common drug interactions include dental caries among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Retin-a and Methotrexate. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Retin-a?

Retin-a has active ingredients of tretinoin. It is often used in acne. eHealthMe is studying from 2,475 Retin-a users. Check the latest studies of Retin-a.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 09, 2026

58 people who take Retin-a and Methotrexate together, and have interactions are studied.

Retin-a and Methotrexate drug interactions.

What are the common drug interactions of Retin-A and Methotrexate, by gender? *:

female:

Dental caries
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Dry mouth
Dysgeusia (disorder of the sense of taste)
Dysuria (painful or difficult urination)
Gallbladder disorder
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Anaphylactic reaction (serious allergic reaction)
Arthralgia (joint pain)
Headache (pain in head)

male:

Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Dizziness
Fall
Head injury
Heart rate decreased
Hyperventilation

What are the common drug interactions of Retin-A and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Dizziness
Fall
Head injury
Heart rate decreased
Hyperventilation
Hypotension (abnormally low blood pressure)
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Loss of consciousness

20-29:

Anal abscess
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Gallbladder disorder
Intestinal obstruction
Organ failure

30-39:

Headache (pain in head)
Injection site erythema (redness at injection site)
Injection site pain
Injection site papule (solid pimple or swelling at injection site)
Injection site pruritus (severe itching at injection site)
Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Precancerous skin lesion
Procedural pain
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)

40-49:

n/a

50-59:

Costochondritis (chest wall pain)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Animal scratch
Erythema (redness of the skin)
Localised infection (infection at the single location)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pain in extremity
Peripheral swelling

60+:

Anaphylactic reaction (serious allergic reaction)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Drug hypersensitivity
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphoria (generalized dissatisfaction with life)
Ear pain
Fatigue (feeling of tiredness)
Gait disturbance

What are the existing conditions these people have? *

Dizziness: 40 people, 68.97%
Pain: 15 people, 25.86%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 6.90%
Osteoporosis (bones weak and more likely to break): 3 people, 5.17%
Depression: 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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