Activase and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activase (alteplase) and Metformin (metformin hydrochloride). Common drug interactions include haemorrhage intracranial among females and arthropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Activase and Metformin. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

On Aug, 04, 2026

65 people who take Activase and Metformin together, and have interactions are studied.

Activase and Metformin drug interactions.

What are the common drug interactions of Activase and Metformin, by gender? *:

female:

Haemorrhage intracranial (bleeding within the skull)
Death
Dyspnoea (difficult or laboured respiration)
Swollen tongue (swelling of tongue)
Asthenia (weakness)
Blood pressure increased
Dehydration (dryness resulting from the removal of water)
Dizziness
Haemorrhage (bleeding)
Vomiting

male:

Arthropathy
Osteoporosis (bones weak and more likely to break)
Haematochezia (passage of stools containing blood)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Light chain analysis increased
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)

What are the common drug interactions of Activase and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Febrile neutropenia (fever with reduced white blood cells)
Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angioedema (rapid swelling of the dermis)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Aortic valve incompetence

50-59:

Exostosis (formation of new bone on the surface of a bone)
Haematochezia (passage of stools containing blood)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Light chain analysis increased
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)

60+:

Angioedema (rapid swelling of the dermis)
Haemorrhage intracranial (bleeding within the skull)
Disease progression
Haemorrhage (bleeding)
Urticaria (rash of round, red welts on the skin that itch intensely)
Arthropathy
Cardiac failure congestive
Cerebral haemorrhage (bleeding within the brain)
Coma (state of unconsciousness lasting more than six hours)
Depression

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 16.92%
Ischaemic Stroke (stroke; caused by an interruption in the flow of blood to the brain): 10 people, 15.38%
Type 2 Diabetes: 5 people, 7.69%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 7.69%
Nausea (feeling of having an urge to vomit): 5 people, 7.69%
Thrombolysis (resolving the blood clot): 4 people, 6.15%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 6.15%
High Blood Pressure: 4 people, 6.15%
Acute Myocardial Infarction (acute heart attack): 4 people, 6.15%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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