Activella and Diflucan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activella (estradiol; norethindrone acetate) and Diflucan (fluconazole). Common drug interactions include abdominal pain upper among females.

The phase IV clinical study analyzes what interactions people have when they take Activella and Diflucan. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

On Jul, 11, 2026

23 people who take Activella and Diflucan together, and have interactions are studied.

Activella and Diflucan drug interactions.

What are the common drug interactions of Activella and Diflucan, by gender? *:

female:

Abdominal pain upper
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pain
Actinomycosis (infection that causes sores, or abscesses)
Anaemia (lack of blood)
Body temperature increased
Bone disorder
Candidiasis (candidiasis or thrush is a fungal infection)
Congestive cardiomyopathy (weakening of heart muscle)
Cough

male:

n/a

What are the common drug interactions of Activella and Diflucan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depression
Thyroid mass
Abdominal pain upper
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Abdominal pain upper
Congestive cardiomyopathy (weakening of heart muscle)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Diplopia (double vision)
Discomfort
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness

60+:

Breast cancer

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 12 people, 52.17%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 3 people, 13.04%
Hot Flush (sudden feelings of heat): 3 people, 13.04%
Menopausal Symptoms: 2 people, 8.70%
High Blood Pressure: 2 people, 8.70%
Dysmenorrhea (painful menstruation): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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