Activella and Nexium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activella (estradiol; norethindrone acetate) and Nexium (esomeprazole magnesium). Common drug interactions include chest pain among females and breast cancer among males.

The phase IV clinical study analyzes what interactions people have when they take Activella and Nexium. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

60 people who take Activella and Nexium together, and have interactions are studied.

What are the common drug interactions of Activella and Nexium, by gender? *:

female:

Chest pain
Diarrhoea
Dizziness
Flatulence (flatus expelled through the anus)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Abdominal pain
Abdominal pain upper
Anxiety

male:

Breast cancer
Drug dependence
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Activella and Nexium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

Chronic kidney disease
Renal injury (kidney injury)
Chest pain

50-59:

Chronic kidney disease
Renal injury (kidney injury)
Breast cancer
Renal failure (kidney dysfunction)
Breast cancer female
Breast cancer stage i
Cutaneous sarcoidosis (a multisystem disease with skin lesion)
Angioedema (rapid swelling of the dermis)
Anxiety
Back injury

60+:

Chronic kidney disease
Pain
Bone disorder
Breast cancer
Defaecation urgency (a sudden compelling urge to defecate)
Diarrhoea
Dizziness
Drug dependence
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

High Blood Cholesterol: 8 people, 13.33%
High Blood Pressure: 8 people, 13.33%
Menopausal Symptoms: 8 people, 13.33%
Pain: 7 people, 11.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 11.67%
Depression: 7 people, 11.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 10.00%
Headache (pain in head): 6 people, 10.00%
Asthma: 6 people, 10.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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