Actonel and Estrogel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actonel (risedronate sodium) and Estrogel (estradiol). Common drug interactions include gastrooesophageal reflux disease among females.

The phase IV clinical study analyzes what interactions people have when they take Actonel and Estrogel. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Estrogel?

Estrogel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 2,921 Estrogel users. Check the latest studies of Estrogel.

On Jul, 12, 2026

15 people who take Actonel and Estrogel together, and have interactions are studied.

What are the common drug interactions of Actonel and Estrogel, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Iron deficiency anaemia
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Embolism venous (embolus may pass into the arterial system)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Female genital tract fistula (passage in genital tract of female)
Fungal infection

male:

n/a

What are the common drug interactions of Actonel and Estrogel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Fall
Acne (skin problems that cause pimples)
Blood sodium decreased
Burning sensation
Fatigue (feeling of tiredness)
Gait disturbance
Heart rate decreased
Hyperaesthesia
Loss of consciousness
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

50-59:

Atypical femur fracture
Back pain
Fall
Plasma cell myeloma (cancer that begins in plasma cells)
Scapula fracture (a fracture of the scapula, the shoulder blade)
Arthralgia (joint pain)
Drug ineffective
Infusion related reaction
Swelling face

60+:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Iron deficiency anaemia
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Embolism venous (embolus may pass into the arterial system)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Female genital tract fistula (passage in genital tract of female)
Fungal infection

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 20.00%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 2 people, 13.33%
Seasonal Allergy (allergic condition due to certain season): 1 person, 6.67%
Patella Fracture: 1 person, 6.67%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 6.67%
Musculoskeletal Disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 1 person, 6.67%
Multiple Myeloma (cancer of the plasma cells): 1 person, 6.67%
Menopausal Symptoms: 1 person, 6.67%
Indigestion: 1 person, 6.67%
Hypotension (abnormally low blood pressure): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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