Actonel and Ofev drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actonel (risedronate sodium) and Ofev (nintedanib esylate). Common drug interactions include decreased appetite among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Actonel and Ofev. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Ofev?

Ofev has active ingredients of nintedanib esylate. eHealthMe is studying from 24,790 Ofev users. Check the latest studies of Ofev.

On Dec, 29, 2025

18 people who take Actonel and Ofev together, and have interactions are studied.

What are the common drug interactions of Actonel and Ofev, by gender? *:

female:

Decreased appetite
Hypotonic urinary bladder (low muscle tone of urinary bladder)
Tendon rupture (tear of tendon)
Death
Bowen's disease (early stage of skin cancer)
Diarrhoea
Dyspepsia (indigestion)
Epistaxis (bleed from the nose)
Gangrene (body tissue dies)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Weight decreased
Frequent bowel movements
Back pain
Dyspnoea exertional (breathlessness or shortness of breath)
Increased appetite
Intervertebral disc protrusion (spinal disc protrusion)
Productive cough
Respiratory distress (difficulty in breathing)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Pulmonary function test decreased

What are the common drug interactions of Actonel and Ofev, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Blood pressure systolic increased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Cough
Crepitations (noises are produced by the rubbing of parts one against the other)
Diarrhoea
Diastolic dysfunction
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)

60+:

Weight decreased
Decreased appetite
Back pain
Dyspnoea exertional (breathlessness or shortness of breath)
Increased appetite
Intervertebral disc protrusion (spinal disc protrusion)
Productive cough
Respiratory distress (difficulty in breathing)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Pulmonary function test decreased

What are the existing conditions these people have? *

Idiopathic Pulmonary Fibrosis (chronic lung disease): 12 people, 66.67%
Osteopenia (a condition where bone mineral density is lower than normal): 8 people, 44.44%
Cough: 8 people, 44.44%
Collagen Disorder (infection and weakness of collagen): 8 people, 44.44%
Interstitial Lung Disease: 4 people, 22.22%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 5.56%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 1 person, 5.56%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 5.56%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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