Actos and Kytril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Kytril (granisetron hydrochloride). Common drug interactions include mouth ulceration among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Kytril. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Kytril?

Kytril has active ingredients of granisetron hydrochloride. eHealthMe is studying from 10,766 Kytril users. Check the latest studies of Kytril.

On Jul, 12, 2026

56 people who take Actos and Kytril together, and have interactions are studied.

What are the common drug interactions of Actos and Kytril, by gender? *:

female:

Mouth ulceration (mouth ulcers)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oesophageal disorder (disease of oesophagus)
Osteomalacia (softening of the bones due to a lack of vitamin d)
Pain in jaw
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Phlebitis (inflammation of the walls of a vein)
Pleural effusion (water on the lungs)
Pleural fibrosis (formation of fibrous tissue in lung)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Ascites (accumulation of fluid in the abdominal cavity)
Pyrexia (fever)
Venous thrombosis limb (blood clot that forms in a vein in the limb)
Anaplastic astrocytoma (tumour of the glial (supportive) tissue of the brain)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Asthenia (weakness)
Blood creatinine increased

What are the common drug interactions of Actos and Kytril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia of chronic disease
Anaphylactic reaction (serious allergic reaction)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angioedema (rapid swelling of the dermis)
Anxiety
Arrhythmia (irregular heartbeat)
Arteritis (inflammation of the walls of arteries)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Bone disorder
Breath odour
Gingival disorder (gum disease)
Gingival pain (gum pain)
Hip fracture
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing
Lymphadenopathy (disease or enlargement of lymph nodes)

40-49:

Anaplastic astrocytoma (tumour of the glial (supportive) tissue of the brain)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Cardiac disorder
Cardiovascular disorder (heart diseases)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Neoplasm recurrence (reoccurrence of tumour)

50-59:

Bladder transitional cell carcinoma (types of bladder cancer)
Blood creatinine increased
Blood urea increased
Dizziness
Dizziness postural
Fall
Fatigue (feeling of tiredness)
Heart rate increased
Hyperglycaemia (high blood sugar)
Hypotension (abnormally low blood pressure)

60+:

Diarrhoea
Bone disorder
Mastication disorder (disease of chewing food)
Nausea (feeling of having an urge to vomit)
Oesophagitis (inflammation of oesophagus)
Osteomyelitis (infection of bone)
Pneumonia
Weight decreased
Abdominal pain
Anaemia of chronic disease

What are the existing conditions these people have? *

Anaemia (lack of blood): 12 people, 21.43%
Stress And Anxiety: 11 people, 19.64%
Pain In Jaw: 11 people, 19.64%
Multiple Myeloma (cancer of the plasma cells): 11 people, 19.64%
Constipation: 11 people, 19.64%
High Blood Pressure: 6 people, 10.71%
Ovarian Cancer (cancer of ovary): 5 people, 8.93%
Pancreatic Carcinoma (pancreatic cancer): 3 people, 5.36%
Nausea (feeling of having an urge to vomit): 3 people, 5.36%
Hypokalemia (low potassium): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and Kytril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously