Excedrin and Ortho evra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Ortho evra (ethinyl estradiol; norelgestromin). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Ortho evra. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Ortho evra?

Ortho evra has active ingredients of ethinyl estradiol; norelgestromin. It is often used in birth control. eHealthMe is studying from 29,275 Ortho evra users. Check the latest studies of Ortho evra.

On Jul, 12, 2026

43 people who take Excedrin and Ortho evra together, and have interactions are studied.

Excedrin and Ortho evra drug interactions.

What are the common drug interactions of Excedrin and Ortho Evra, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Dissociation
Fibromyalgia (a long-term condition which causes pain all over the body)
Iron deficiency anaemia
Irritability
Mood altered (changes in mood)
Muscle twitching
Panic attack
Post-traumatic stress disorder

male:

n/a

What are the common drug interactions of Excedrin and Ortho Evra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cerebral haemorrhage (bleeding within the brain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Transverse sinus thrombosis (a blood clot in transverse sinus)
Nausea (feeling of having an urge to vomit)
Metrorrhagia (uterine bleeding at irregular intervals)
Vision blurred
Application site reaction
Depression
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Vomiting

30-39:

Application site reaction
Decreased appetite
Depression
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Metrorrhagia (uterine bleeding at irregular intervals)

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Injection site erythema (redness at injection site)
Injection site pain
Periorbital cellulitis (inflammation and infection of the eyelid and the skin surrounding the eye)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 30.23%
Nausea (feeling of having an urge to vomit): 7 people, 16.28%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and Ortho evra?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously