Actos and Peginterferon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Peginterferon (peginterferon alfa-2a; ribavirin). Common drug interactions include agranulocytosis among females and erythema multiforme among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Peginterferon. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Peginterferon?

Peginterferon has active ingredients of peginterferon alfa-2a; ribavirin. It is often used in hepatitis c. eHealthMe is studying from 13,778 Peginterferon users. Check the latest studies of Peginterferon.

On Jul, 19, 2026

39 people who take Actos and Peginterferon together, and have interactions are studied.

Actos and Peginterferon drug interactions.

What are the common drug interactions of Actos and Peginterferon, by gender? *:

female:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Rash
Diarrhoea
Abdominal discomfort
Blood uric acid decreased
Cough
Dizziness postural
Haemoglobin decreased
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased

male:

Erythema multiforme (a type of hypersensitivity reaction)
Platelet count decreased
Ear canal abrasion
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hepatic steatosis (fatty liver disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Non-hodgkin's lymphoma stage iii (malignant (cancer) cells form in the lymph system- stage iii)
Persecutory delusion
Rash
Splenomegaly (enlargement of spleen)

What are the common drug interactions of Actos and Peginterferon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Persecutory delusion

40-49:

Acute hepatic failure
Hepatic steatosis (fatty liver disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Non-hodgkin's lymphoma stage iii (malignant (cancer) cells form in the lymph system- stage iii)
Renal impairment (severely reduced kidney function)
Splenomegaly (enlargement of spleen)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

50-59:

Blood glucose increased
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)
Retinal haemorrhage (bleeding from retina)
Retinal exudates (discharge from retina)
Retinopathy (acute damage to the retina of the eye)

60+:

Platelet count decreased
Rash
Anaemia (lack of blood)
White blood cell count decreased
Erythema multiforme (a type of hypersensitivity reaction)
Drug eruption (adverse drug reaction of the skin)
Pyrexia (fever)
Bladder neoplasm (bladder tumour)
Renal impairment (severely reduced kidney function)
Skull fractured base

What are the existing conditions these people have? *

Insulin Resistance: 3 people, 7.69%
Type 2 Diabetes: 2 people, 5.13%
High Blood Pressure: 2 people, 5.13%
Diarrhea: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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