Actos and Repatha drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Repatha (evolocumab). Common drug interactions include abdominal pain upper among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Repatha. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

On Jul, 31, 2026

21 people who take Actos and Repatha together, and have interactions are studied.

What are the common drug interactions of Actos and Repatha, by gender? *:

female:

Abdominal pain upper
Arthralgia (joint pain)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Blood cholesterol decreased
Blood pressure increased
Diabetes mellitus inadequate control
Back pain
Dizziness
Fatigue (feeling of tiredness)

male:

Pain
Headache (pain in head)
Visual impairment
Chills (felling of cold)
Confusional state
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Dizziness
Feeling cold
Gait disturbance
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Actos and Repatha, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Renal failure (kidney dysfunction)

50-59:

Abdominal pain upper
Dizziness
Hemiparesis (weakness on one side of the body)
Nausea (feeling of having an urge to vomit)
Pain
Rash

60+:

Pain
Headache (pain in head)
Vision blurred
Visual impairment
Chills (felling of cold)
Confusional state
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Dizziness
Feeling cold
Gait disturbance

What are the existing conditions these people have? *

Stress And Anxiety: 4 people, 19.05%
Insomnia (sleeplessness): 3 people, 14.29%
Chest Pain: 3 people, 14.29%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 3 people, 14.29%
High Blood Pressure: 3 people, 14.29%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 14.29%
Low Density Lipoprotein Increased (cholesterol increased in blood): 3 people, 14.29%
Pain: 3 people, 14.29%
Sleep Disorder: 3 people, 14.29%
Indigestion: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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