Acyclovir sodium and Itraconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acyclovir sodium (acyclovir sodium) and Itraconazole (itraconazole). Common drug interactions include diarrhoea among females and hypercalcaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Acyclovir sodium and Itraconazole. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Acyclovir sodium?

Acyclovir sodium has active ingredients of acyclovir sodium. eHealthMe is studying from 1,813 Acyclovir sodium users. Check the latest studies of Acyclovir sodium.

What is Itraconazole?

Itraconazole has active ingredients of itraconazole. It is often used in fungal infection. eHealthMe is studying from 12,372 Itraconazole users. Check the latest studies of Itraconazole.

On Jul, 13, 2026

45 people who take Acyclovir sodium and Itraconazole together, and have interactions are studied.

Acyclovir sodium and Itraconazole drug interactions.

What are the common drug interactions of Acyclovir Sodium and Itraconazole, by gender? *:

female:

Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haemorrhage subcutaneous (bleeding from skin)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Malignant neoplasm progression (cancer tumour came back)
Multi-organ failure (multisystem organ failure)
Multiple myeloma (cancer of the plasma cells)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Platelet count decreased

male:

Hypercalcaemia (elevated calcium (ca+) level in the blood)
Renal failure acute (rapid kidney dysfunction)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Platelet count decreased
Pneumonia
Renal impairment (severely reduced kidney function)
Abdominal pain upper
Acanthamoeba infection (acanthamoeba infection is a cutaneous condition)
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute sinusitis

What are the common drug interactions of Acyclovir Sodium and Itraconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

General physical health deterioration (weak health status)
Neutropenia (an abnormally low number of neutrophils)
Oesophagitis (inflammation of oesophagus)
Renal impairment (severely reduced kidney function)
Thrombocytopenia (decrease of platelets in blood)

20-29:

Hypertension (high blood pressure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Klebsiella sepsis (klebsiella causes a potentially fatal whole-body inflammation)
Liver disorder (liver diseases)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pericardial effusion (fluid around the heart)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Renal disorder (kidney disease)
Thrombocytopenia (decrease of platelets in blood)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

30-39:

Hypercalcaemia (elevated calcium (ca+) level in the blood)
Renal failure acute (rapid kidney dysfunction)
Retinoic acid syndrome (complication of blood cancer treatment with tretinoin)
Mucosal inflammation (infection of mucous membrane)
Muscle atrophy (a decrease in the mass of the muscle)
Muscle contractions involuntary (uncontrolled muscle contraction)
Muscular weakness (muscle weakness)
Neuropathy peripheral (surface nerve damage)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Transplant failure (transplantation failed to meet outcome)

40-49:

Anal abscess
Thrombocytopenia (decrease of platelets in blood)
Platelet count decreased
Respiratory failure (inadequate gas exchange by the respiratory system)
Drug ineffective
Abdominal pain upper
Acanthamoeba infection (acanthamoeba infection is a cutaneous condition)
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute sinusitis
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)

50-59:

Depression
Endophthalmitis (inflammation of the internal coats of the eye)
Keratitis fungal (inflammation of the cornea due to fungal organism)
Nausea (feeling of having an urge to vomit)
Blood calcium increased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Infection
Malignant neoplasm progression (cancer tumour came back)
Multi-organ failure (multisystem organ failure)

60+:

Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Septic shock (shock due to blood infection)
Therapeutic response decreased (less preventive response)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
White blood cell count decreased
Bacterial sepsis
Blood urea increased
Blood uric acid increased
Enterocolitis bacterial

What are the existing conditions these people have? *

Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 9 people, 20.00%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 6 people, 13.33%
Multiple Myeloma (cancer of the plasma cells): 5 people, 11.11%
Bone Marrow Conditioning Regimen: 4 people, 8.89%
Acute Promyelocytic Leukaemia (cancer of the blood and bone marrow): 4 people, 8.89%
White Blood Cell Count Decreased: 3 people, 6.67%
Diarrhea: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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