Cogentin and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cogentin (benztropine mesylate) and Spironolactone (spironolactone). Common drug interactions include dehydration among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Cogentin and Spironolactone. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

On Jul, 13, 2026

37 people who take Cogentin and Spironolactone together, and have interactions are studied.

Cogentin and Spironolactone drug interactions.

What are the common drug interactions of Cogentin and Spironolactone, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diarrhoea
Dry mouth
Ear discomfort
Ear pain
Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear)
Erythema (redness of the skin)
Facial pain
Gingival bleeding (bleeding gums)

male:

Diarrhoea
Abdominal pain upper
Acute psychosis (period of mentally unstable behaviour)
Back injury
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Contusion (a type of hematoma of tissue in which capillaries)
Diabetic coma

What are the common drug interactions of Cogentin and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deafness
Ear infection
Weight increased
Acute psychosis (period of mentally unstable behaviour)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Contusion (a type of hematoma of tissue in which capillaries)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic foot infection
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

40-49:

Joint sprain (an injury to joint surrounding flexible fibres)
Joint swelling
Lymphoedema (localized fluid retention and tissue swelling)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Malaise (a feeling of general discomfort or uneasiness)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Myalgia (muscle pain)
Myopathy (a muscular disease in which the muscle fibres do not function)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

Mood swings (an extreme or rapid change in mood)
Abdominal pain upper
Decreased appetite
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Hypersomnia (excessive daytime sleepiness (eds))
Insomnia (sleeplessness)
Lip disorder (disease of lip)

60+:

Blood pressure decreased
Blood urea increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Diarrhea: 6 people, 16.22%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 13.51%
Psychotic Disorder: 4 people, 10.81%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 10.81%
Osteoporosis (bones weak and more likely to break): 4 people, 10.81%
Depression: 4 people, 10.81%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 8.11%
Pain: 3 people, 8.11%
Bipolar Disorder (mood disorder): 3 people, 8.11%
Throat Irritation: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Cogentin and Spironolactone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously